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ProteomicsThe pseudokinase NRBP1 activates Rac/Cdc42 via P-Rex1 to drive oncogenic signalling in triple negative breast cancer
In an effort to identify oncogenic protein kinase drivers in triple negative breast cancer (TNBC), we undertook mass spectrometry (MS)-based proteomic profiling across a large panel of TNBC cell lines. This revealed marked variation in expression of the multidomain pseudokinase Nuclear Receptor Bind...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD032168 | Pride
G proteins Proteomics Signal transduction Scaffold proteins 
UnknownNRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.
Not available
S-EPMC12266122 | biostudies-literature
UnknownThe pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
Not available
S-EPMC10005955 | biostudies-literature
ProteomicsNRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress - Figure 1D/S1C
Please refer to the manuscript for a detailed description.
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD062616 | Pride
Osmotic stress Wnk pathway Nrbp1 pseudokinase 
ProteomicsNRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress - Figure 5B / 6A
Please refer to the manuscript for a detailed description.
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD062619 | Pride
Osmotic stress Wnk pathway Nrbp1 pseudokinase 
UnknownNuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer.
Not available
S-EPMC5864759 | biostudies-literature
UnknownIntegrated genomics approach to identify biologically relevant alterations in fewer samples.
Not available
S-EPMC4647579 | biostudies-literature
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