Dataset Information
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress - Figure 5B / 6A
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Frederic Lamoliatte
LAB HEAD: Dario R. Alessi
PROVIDER: PXD062619 | Pride | 2025-07-21
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| FL_20220829_Ram_DA_SA_Description.txt | Txt | |||
| FL_20220829_Ram_DA_SA_DiaNN.zip | Other | |||
| FL_20220829_Ram_DA_SA_Gm1.raw | Raw | |||
| FL_20220829_Ram_DA_SA_Gm2.raw | Raw | |||
| FL_20220829_Ram_DA_SA_Gm3.raw | Raw |
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Publications
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.
Science advances 20250716 29
WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity labeling approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudokinase and TSC22D2/4 adaptor proteins, results that are confirmed by immunoprecipitation, mass spectrometry, and immunoblotting studies. NRBP1 pseudokinase is closely related to WNK isoforms and contains a RΦ-motif-binding conserved C-terminal (CCT) domain, like ...[more]
