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ProteomicsHCV Hypo- vs. Hyper-Phosphorylated NS5A Interactome
Chronic hepatitis C virus (HCV) infection is a leading cause of liver cancer. HCV propagation and oncogenicity depend in part on the phosphorylation states of its non-structural protein 5A (NS5A); however, little is known about how hypo- or hyper-phosphorylated NS5A functions. Here, we segregated hy...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD012767 | Pride
Cancer Antiviral Ns5a Liver Hcv 
TranscriptomicsPolysome profiling of Huh7.5 cells expressing HCV NS5A
Hepatitis C Virus protein NS5A was found to upregulate assembly of cap binding initiation complex eIF4F in Huh7.5 cells. NS5A also was found to associate with translation machinery. To understand consequences of NS5A mediation in host translation, we analyzed mRNA associated with polysome fractions ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-46273 | biostudies-arrayexpress
TranscriptomicsPolysome profiling of Huh7.5 cells expressing HCV NS5A
Hepatitis C Virus protein NS5A was found to upregulate assembly of cap binding initiation complex eIF4F in Huh7.5 cells. NS5A also was found to associate with translation machinery. To understand consequences of NS5A mediation in host translation, we analyzed mRNA associated with polysome fractions ...
ORGANISM(S): Homo sapiens 
2014-05-01 | GSE46273 | GEO
TranscriptomicsThe hepatitis C viral protein NS5A stabilizes growth-regulatory human transcripts
Numerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural protein 5A (NS5A), a protein known to bind to ...
ORGANISM(S): Homo sapiens 
2017-11-01 | GSE102910 | GEO
GenomicsHepatitis C virus subtype 1b
HCV NS5A sequencing
PRJDB2979 | ENA
Genomics
HCV NS5A RASs
PRJNA506351 | ENA
GenomicsHomo sapiens
Polysome profiling of Huh7.5 cells expressing HCV NS5A
PRJNA198502 | ENA
UnknownSynergistic Activity of Combined NS5A Inhibitors.
Not available
S-EPMC4775965 | biostudies-literature
UnknownInteraction between Nonstructural Proteins NS4B and NS5A Is Essential for Proper NS5A Localization and Hepatitis C Virus RNA Replication.
Not available
S-EPMC4984624 | biostudies-literature
UnknownInteractions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation.
Not available
S-EPMC12207731 | biostudies-literature
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