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TranscriptomicsThe blood transcriptional signature of chronic HCV
This SuperSeries is composed of the following subset Series: GSE40184: The blood transcriptional signature of chronic HCV [Affymetrix data] GSE40223: The blood transcriptional signature of chronic HCV [Illumina data] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40224 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Affymetrix data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40184 | biostudies-arrayexpress
ProteomicsQuantitative proteome analysis of plasma microparticles for characterization of HCV-induced hepatic cirrhosis and hepatocellular carcinoma
A quantitative label-free proteome analysis was performed using plasma samples from 22 hepatitis-C virus (HCV)-induced liver cirrhosis patients, 16 HCV-positive hepatocellular carcinoma patients with underlying cirrhosis and 18 healthy controls. Plasma microparticles (PMPS) were isolated using ultra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-12 | MSV000085094 | MassIVE
TranscriptomicsMicroRNAs Profile of HCV Spontaneous Clarified Individuals, Denotes Previous HCV Infection
Hepatitis C virus (HCV) remains a significant public health threat as new 1.75 million HCV infections emerged worldwide. The majority of these infections become persistently infected, while around 30 % spontaneously eliminate the virus. Clinical factors for viral clarification are related to HCV int...
ORGANISM(S): Homo sapiens 
2019-06-21 | E-MTAB-8023 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Illumina data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40223 | biostudies-arrayexpress
Proteomics,MultiomicsHCV Cryoprecipitate LC-MS/MS with iTRAQ Quantification
The discovery of hepatitis C virus (HCV) in 1989 revealed the virus as the etiology of 40%-90% of the “essential” mixed cryoglobulinemia, where immune complex forms deposit called cryoprecipitate at temperatures below 37 °C. Cryoprecipitate constitutes monoclonal IgM and polyclonal IgG, some of whic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-31 | MSV000085207 | MassIVE
TranscriptomicsEndogenous Intrahepatic Interferons and Association with IFN-free HCV Treatment Outcome
Hepatitis C virus (HCV) chronically infects 170 million people worldwide and is a leading cause of liver-related mortality due to hepatocellular carcinoma and cirrhosis1. Standard-of-care treatment is shifting from interferon-alpha (IFNM-NM-1)-based to IFNM-NM-1-free directly acting antiviral (DAA)...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-51699 | biostudies-arrayexpress
ProteomicsHCV Hypo- vs. Hyper-Phosphorylated NS5A Interactome
Chronic hepatitis C virus (HCV) infection is a leading cause of liver cancer. HCV propagation and oncogenicity depend in part on the phosphorylation states of its non-structural protein 5A (NS5A); however, little is known about how hypo- or hyper-phosphorylated NS5A functions. Here, we segregated hy...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD012767 | Pride
Cancer Antiviral Ns5a Liver Hcv 
TranscriptomicsCpG site methylation of HCV-cirrhotic, HCV-HCC, and normal liver tissues
In this study we used a high-throughput method for assaying methylation of CpG sites simultaneously in a single sample for identifying differences in methylation observed in tissues ranging from normal liver to pre-neoplastic (cirrhosis) and neoplastic (HCC) states. Since there are important clinica...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-GEOD-18081 | biostudies-arrayexpress
ProteomicsHIV/HCV co-infection proteomics
Hepatic complications of HCV infection, including fibrosis and cirrhosis are accelerated in HIV-infected individuals. Although liver biopsy remains the gold standard for staging HCV-associated liver disease, this test can result in serious complications and is subject to sampling error. These challe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD009007 | Pride
Seldi Proteomics Hcv Co-infection Liver Fibrosis Hiv Maldi Biomarker discovery Human 
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