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TranscriptomicsIdentification of novel metastases-suppressor genes involved in lung cancer brain metastases formation.
Initial screening for potential metastases suppressors down regulated by methylation was performed using lung cancer cell line models specific for site-specific metastasation. Gene expression profiling and qRT-PCR validations were conducted on tumor tissues from primary lung cancer (LC) and brain me...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-57492 | biostudies-arrayexpress
ProteomicsCathepsin F and Fibulin-1 as novel diagnostic biomarkers for Brain Metastasis of Non-Small Cell Lung Cancer
Background: There is a paucity of non-invasive markers for early detection of brain metastasis (BM) in patients with non-small cell lung cancer (NSCLC). Secretory proteomic approach based on quantitative tandem mass tag is believed to offer bright prospects for screening potential serum biomarkers f...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023721 | Pride
Nsclc brain metastasis  proteomics  diagnosis  follow-up  prognosis. 
ProteomicsGenome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumor and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060790 | Pride
Bace1 Egfr 
UnknownExperimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models.
Not available
S-EPMC8497791 | biostudies-literature
UnknownTNF-α enhancement of CD62E mediates adhesion of non-small cell lung cancer cells to brain endothelium via CD15 in lung-brain metastasis.
Not available
S-EPMC4827040 | biostudies-literature
Methylation profilingMethylation profiling of brain metastasis tissue, cerebrospinal spinal (CSF) and plasma from patients with non-small cell lung cancer (NSCLC)
This project investigates genome-wide DNA methylation patterns in tumor, cerebrospinal fluid (CSF), and blood from patients with non-small cell lung cancer (NSCLC) brain metastasis. Brain metastasis tumor tissues obtained at the time of neurosurgical resection performed as part of routine clinical c...
ORGANISM(S): Homo sapiens 
2026-06-12 | GSE327701 | GEO
UnknownMicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration.
Not available
S-EPMC3154499 | biostudies-literature
UnknownDevelopment and validation of a predictive nomogram for leptomeningeal metastasis risk in NSCLC brain metastases: role of tumor location, driver mutations, and stereotactic radiosurgery.
Not available
S-EPMC12511215 | biostudies-literature
UnknownSIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration.
Not available
S-EPMC3816804 | biostudies-literature
UnknownTargeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
Not available
S-EPMC8864012 | biostudies-literature
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