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TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [iCLIP]
Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we a...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44385 | biostudies-arrayexpress
TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [RNA-seq]
Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we a...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44384 | biostudies-arrayexpress
ProteomicsNeuronal Nsun2 deficiency is associated with codon-specific epitranscriptomic dysregulation of Gly-tRNAs and corresponding proteomic shift impacting synaptic signaling and behavior
The role of transfer (t)RNA cytosine methyl-transferases as epitranscriptomic regulators of brain proteomes remains unexplored. We report that fear memory and antidepressant-like behaviors are highly sensitive to bi-directional changes in Nsun2 tRNA methyltransferase activity in prefrontal cortex (P...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-02 | PXD023437 | Pride
Nsun2 Tmt Neurons 
GenomicsLoss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability
Mutations in the cytosine-5 RNA methyltransferase NSun2 can cause Intellectual Disability (ID) and symptoms commonly found in patients with Dubowitz syndrome. By analysing gene expression data with the global cytosine-5 RNA methylome in NSun2-deficient mice, we find that loss of cytosine-5 RNA met...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-44746 | biostudies-arrayexpress
TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44386 | biostudies-arrayexpress
TranscriptomicsThe mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation
Post-transcriptional regulatory mechanisms are crucial for protein synthesis during spermatogenesis and often organized by the chromatoid body. Chromatoid bodies are large cytoplasmic ribonucleoprotein granules, whose precise function and composition remain unclear. Here, we identify NSun2 as a nove...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-39480 | biostudies-arrayexpress
GenomicsNSUN2 mediated m5C modification regulates myocardial hypertrophy
NSUN2 mediated m5C modification regulates myocardial hypertrophy
PRJNA981449 | ENA
ProteomicsInteraction partners with NOP2/Sun RNA methyltransferase 2 (NSUN2) in gallbladder carcinoma
Proteins interacting with NSUN2 in gallbladder carcinoma (NOZ cell line)
ORGANISM(S): Homo Sapiens 
2019-03-20 | PXD013152 |
GenomicsWhole transcriptome bisufilte sequencing for multiple species [NSUN2 verification]
Whole transcriptome bisufilte sequencing for multiple species [NSUN2 verification]
PRJNA673708 | ENA
GenomicsRibosome profiling of wild-type and NSUN2 knockout flies
Ribosome profiling of wild-type and NSUN2 knockout flies
PRJNA673613 | ENA
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