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ProteomicsCUL4A-DDB1-DCAF10 is an n-recognin for Nt-acetylated Src kinases
cotranslational n-terminal modifications such as methionine excision, acetylation, and myristoylation contribute to protein stability, localization and three-dimensional folding. Disruption of these modifcations expose short n-terminal degron motifs that ultimately trigger protein degradation throug...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD061095 | Pride
N-t acetylation Sfks N-degron dcaf10 Ubiquitination Nt- myristoylation Cotranslational modifications N-recognin 
ProteomicsCRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation
N-degron pathway plays an important role in the protein quality control and maintenance of cellular protein homeostasis. ZER1 and ZYG11B, the substrate receptors of the Cullin 2-RING E3 ubiquitin ligase (CRL2), recognize N-terminal (Nt) glycine degrons and participate in the Nt-myristoylation qualit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037312 | Pride
N-terminal acetylation Nt-ser Crl2zer1/zyg11b 
UnknownReciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation.
Not available
S-EPMC6588657 | biostudies-literature
UnknownCRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Not available
S-EPMC9741652 | biostudies-literature
UnknownChemically induced dimerization of GSDMD C-terminal domain blocks GSDMD N-terminal domain-mediated pyroptosis.
Not available
S-EPMC12518871 | biostudies-literature
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