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ProteomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053207 | Pride
Nua4/tip60 acetyltransferase Ep400 complex Chromatin remodeling complex Ncp 
ProteomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053209 | Pride
Nua4/tip60 acetyltransferase P400-ncp complex H2a.z Nua4 and swr1 chromatin modifier and remodeler complexes 
ProteomicsYang_NuA4_TIP60_structural_features
This submission contains the mass spectrometry files for the manuscript by Zhenlin Yang et al. that describes the unique structural features of the NuA4/TIP60 acetyltransferase and chromatin remodeling complex. MS experiments were performed from TAP purified complexes from K562 cells and MS files we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-02 | MSV000093280 | MassIVE
UnknownStructural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.
Not available
S-EPMC11995519 | biostudies-literature
GenomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [RNA-seq]
Unique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [RNA-seq]
PRJNA1088181 | ENA
GenomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [ChIP-seq]
Unique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [ChIP-seq]
PRJNA1088264 | ENA
ProteomicsZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor c...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-21 | PXD023702 | Pride
Acute myeloid leukemia H3k36me3 Bromodomain 
TranscriptomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [RNA-seq]
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens 
2024-08-06 | GSE261651 | GEO
GenomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex [ChIP-seq]
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens 
2024-08-06 | GSE261650 | GEO
UnknownArchitecture of the Saccharomyces cerevisiae NuA4/TIP60 complex.
Not available
S-EPMC5861120 | biostudies-literature
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