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MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14941 | MetaboLights
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14943 | MetaboLights
GenomicsCTCF demarcates chromatin domains
Insulators are DNA elements, which prevent inappropriate interactions between the neighboring regions of the genome. They can be functionally classified as either enhancer blockers or domain barriers. CTCF (CCCTC binding factor) is the only known major insulator binding protein in the vertebrates a...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-12889 | biostudies-arrayexpress
GenomicsNuclear barrier induction as a new modality of cellular senescence
Nuclear barrier induction as a new modality of cellular senescence
PRJNA448140 | ENA
GenomicsFrequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm and the mitochondrial double membrane. Despite these physical barriers we show that somatically acquired mitochondrial-nuclear genome fusion sequences are pres...
EGAS00001001234 | EGA
TranscriptomicsNuclear barrier induction as a new modality of cellular senescence
Blocking of nucleocytoplasmic trafficking is an essential feature of replicative senescence (RS). However, whether nuclear barrier per se causes cellular senescence still remains elusive. Here, we show that nuclear barrier induced by blocking nucleocytoplasmic trafficking, especially nuclear export,...
ORGANISM(S): Homo sapiens 
2021-06-17 | GSE112530 | GEO
TranscriptomicsTranscription profiling of chicken develomental time series of the retinal pigment epithelia
Purpose: The morphology of the RPE shows minimal change as the neural retina and choriocapillaris differentiate. Nonetheless, initial studies of barrier-related proteins suggest extensive remodeling of the RPE in response to this changing environment. A genomic approach was used to investigate the e...
ORGANISM(S): Gallus gallus 
2008-11-08 | E-GEOD-7176 | biostudies-arrayexpress
TranscriptomicsNuclear pore complex evolution: A trypanosome Mlp analog functions in chromosomal segregation but lacks transcriptional barrier activity
The nuclear pore complex (NPC) has dual roles in nucleocytoplasmic transport and chromatin organisation. In many eukaryotes the coiled coil Mlp/Tpr proteins of the NPC nuclear basket have specific roles in interactions with chromatin and defining specialised regions of active transcription, while Ml...
ORGANISM(S): Trypanosoma brucei 
2014-04-03 | E-GEOD-56436 | biostudies-arrayexpress
ProteomicsDisruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
Nuclear barrier Cellular senescence Replicative senescence Eukaryotic aging Nucleocytoplasmic trafficking 
UnknownNuclear Envelope Permeability Barrier as a Fast-Response Intracellular Mechanostat.
Not available
S-EPMC6839651 | biostudies-literature
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