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ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
TranscriptomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
2025-11-12 | E-MTAB-12712 | biostudies-arrayexpress
GenomicsLamin B2 controls nuclear envelope permeability and regulates cardiomyocyte regeneration
Lamin B2 controls nuclear envelope permeability and regulates cardiomyocyte regeneration
PRJNA423262 | ENA
TranscriptomicsRNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury
This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...
ORGANISM(S): Rattus norvegicus 
2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress
GenomicsFAK is required for suppressing aberrant nuclear mechanotransduction and DNA methylation to prevent vascular injury
FAK is required for suppressing aberrant nuclear mechanotransduction and DNA methylation to prevent vascular injury
PRJNA857070 | ENA
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
UnknownRecruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
Not available
S-EPMC7758627 | biostudies-literature
UnknownThe brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K.
Not available
S-EPMC10642205 | biostudies-literature
TranscriptomicsThe TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
There is considerable evidence that inhibition of p38α mitogen-activated protein kinase diminishes cardiac damage during myocardial ischemia. During myocardial ischemia p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then trans-phosphorylates TAB...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6460 | biostudies-arrayexpress
TranscriptomicsAcute and chronic liver injury change the small RNA cargoes carried by serum small extracellular vesicles in mice
Compared to whole serum miRNAs, miRNAs in serum small extracellular vesicles (sEVs) are well protected form RNA enzymes, thus provide a consistent source of miRNA for disease biomarker detection. Serum sEVs and their miRNA cargos released by injured liver cells could be promising biomarkers for diag...
ORGANISM(S): Mus musculus 
2021-08-07 | E-MTAB-9462 | biostudies-arrayexpress
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