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GenomicsNuclear envelope rupture causes RNA polymerase loss in LMNA cardiomyopathy
Nuclear envelope rupture causes RNA polymerase loss in LMNA cardiomyopathy
PRJNA1438739 | ENA
ProteomicsDNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of Lamin A/C
The integrity of the nuclear envelope (NE) is essential to maintain the structural stability of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in the context of mechanical challenges, such as physical confinement and migration. However, spontaneous NE rupture...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD040857 | Pride
Atr Ne vulnerability Nuclear envelope rupture Hr-deficiency Lamina Lamin a/c phosphorylation Dna damage Synthetic lethality Targeted therapy Replication stress 
GenomicsMechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Ndc1 KD)
Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Ndc1 KD)
PRJNA1375538 | ENA
ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
GenomicsNuclear envelope rupture causes RNA polymerase loss in LMNA cardiomyopathy
Localized rupture of the nuclear envelope has been reported in various pathologies, including cancer, neurodegenerative disease, myocardial infarction, as well as dilated cardiomyopathy caused by Lamin A/C gene mutations (LMNA-DCM). Whether and how nuclear rupture contributes to disease remains uncl...
ORGANISM(S): Mus musculus 
2026-04-03 | GSE325163 | GEO
GenomicsActin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages
Actin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages
PRJNA1201051 | ENA
ProteomicsDNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of Lamin A/C - Synthetic Peptide
The integrity of the nuclear envelope (NE) is essential to maintain the structural stability of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in the context of mechanical challenges, such as physical confinement and migration. However, spontaneous NE rupture...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043990 | Pride
Atr Ne vulnerability Nuclear envelope rupture Hr-deficiency Lamina Lamin a/c phosphorylation Dna damage Synthetic lethality 
GenomicsMechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Stereo-seq)
Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Stereo-seq)
PRJNA1542969 | ENA
GenomicsActin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages I
Actin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages I
PRJNA1201748 | ENA
GenomicsMechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Lmna KO)
Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor–Stromal Interactions (Lmna KO)
PRJNA1464709 | ENA
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