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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness (part 2: Surface and Nuclear Proteomes)
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027268 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Surface and nuclear proteome Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness.
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027217 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
GenomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness
Nuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness
PRJNA745564 | ENA
TranscriptomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK signa...
ORGANISM(S): Homo sapiens 
2021-09-30 | GSE179901 | GEO
UnknownG-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.
Not available
S-EPMC5013524 | biostudies-literature
UnknownNuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.
Not available
S-EPMC8613289 | biostudies-literature
UnknownThe prophase oocyte nucleus is a homeostatic G-actin buffer.
Not available
S-EPMC8977058 | biostudies-literature
UnknownLong Noncoding RNA CRYBG3 Blocks Cytokinesis by Directly Binding G-Actin.
Not available
S-EPMC6095725 | biostudies-literature
UnknownVIP Induces Changes in the F-/G-Actin Ratio of Schlemm's Canal Endothelium via LRRK2 Transcriptional Regulation.
Not available
S-EPMC7415318 | biostudies-literature
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