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ProteomicsIdentifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
Background: The intracellular pathogen Mycobacterium tuberculosis is known to encounter several stress conditions during infection, including low pH, hypoxia, starvation and oxidative and nitrosative stress. Mycobacterial adaptation to stress conditions is, in part, mediated by several nucleic acid-...
ORGANISM(S): Mycobacterium smegmatis Bacteria 
2020-03-05 | PXD016241 | Pride
Nucleic acid-associated proteins Affinity-purification Mycobacterium Rna polymerase 
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
ProteomicsEnrichment strategy for searching missing protein
Enrichment strategy for searching missing protein is a project under the guidance of Chromosome-Centric Human Proteome Project (C-HPP). We developed systematical enrichment strategies for revealing the existence of MPs including low molecular weight (LMW), membrane proteins, post-translational modif...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083957 | MassIVE
UnknownIdentifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics.
Not available
S-EPMC7092591 | biostudies-literature
GenomicsExperimental characterization of the human non-sequence-specific nucleic acid interactome
The interactions between proteins and nucleic acids have a fundamental function in many biological processes well beyond nuclear gene transcription and include RNA homeostasis, protein translation and pathogen sensing for innate immunity. While our knowledge of the ensemble of proteins binding indiv...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-47539 | biostudies-arrayexpress
TranscriptomicsSR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase
RNAP II is frequently paused near gene promoters in mammals and its transition to productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II and other key transcription elongation factors. A fraction of P-TEFb is sequestered in an inhibitory complex containing...
ORGANISM(S): Mus musculus 
2013-05-09 | E-GEOD-45517 | biostudies-arrayexpress
GenomicsProteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)
Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
GenomicsExperimental characterization of the human non-sequence-specific nucleic acid interactome
The interactions between proteins and nucleic acids have a fundamental function in many biological processes well beyond nuclear gene transcription and include RNA homeostasis, protein translation and pathogen sensing for innate immunity. While our knowledge of the ensemble of proteins binding indiv...
ORGANISM(S): Homo sapiens 
2013-06-18 | GSE47539 | GEO
UnknownPathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases.
Not available
S-EPMC5425713 | biostudies-literature
TranscriptomicsA quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins (CLIP)
Crosslinking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins (RBPs). We developed a method for CLIP data analysis and applied it to compare 254 nm CLIP with PAR-CLIP, which involves crosslinking of photoreactive nucleotides with 365...
ORGANISM(S): Homo sapiens 
2011-05-15 | E-GEOD-28859 | biostudies-arrayexpress
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