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ProteomicsProteomic profile of oxaliplatin treated cell line reveals DNA damage induced nucleolar stress as main response.Proteomic profile of oxaliplatin treated cell line reveals DNA damage induced nucleolar stress as main response
Oxaliplatin is a widely used anti-cancer drug. It is part of treatment regimens for colorectal and pancreatic cancers, but it is tested in esophageal, biliary tract, gastric or hepatocellular cancers as well. Contrary to this wide application, there is only limited amount of information about oxalip...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD003543 | Pride
Proteomics Oxaliplatin Lc-ms Ribosomal stress Nucleolar stress 
ProteomicsKLF16 enhances stress tolerance of colorectal carcinomas by modulating nucleolar homeostasis and translational reprogramming
Translational reprogramming is part of the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, which acts to the advantage of cancer growth and development in different stress conditions. But the mechanism of ER stress-related translational reprogramming in colorectal carcinoma...
ORGANISM(S): Homo Sapiens 
2022-05-16 | PXD033930 |
ProteomicsRibosomal/nucleolar stress induction regulates tert-butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts
A general understanding of redox homeostasis in An. gambiae midgut epithelial cells under different oxidative conditions during P. falciparum ookinete invasion is missing. We used an ex vivo midgut culture model to understand AgTrx-1 protein expression pattern in An. gambiae midguts under oxidative ...
ORGANISM(S): Anopheles gambiae (African malaria mosquito) 
2018-11-21 | PXD008251 | Pride
Malaria Tert butyl hydroperoxide Ribosomal stress Anopheles gambiae Nucleolar stress Oxidative stress 
GenomicsQuinacrine induces nucleolar stress in treatment-refractory ovarian cancer
Quinacrine induces nucleolar stress in treatment-refractory ovarian cancer
PRJNA735553 | ENA
GenomicsNeutrophil nucleolar stress rapidly releases nucleoli-stored IFNα during infection
Neutrophil nucleolar stress rapidly releases nucleoli-stored IFNα during infection
PRJNA1463803 | ENA
GenomicsAnalysis of gene expression change in cancer cells induced by nucleolar stress
Analysis of gene expression change in cancer cells induced by nucleolar stress
PRJNA731247 | ENA
UnknownDouble-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair.
Not available
S-EPMC6735822 | biostudies-literature
UnknownNucleolar stress: is there a reverse version?
Not available
S-EPMC6216007 | biostudies-literature
TranscriptomicsA potential role for snoRNA in PKR activation during metabolic stress
PKR (Protein Kinase RNA-activated) is activated by metabolic stress, such as that associated with obesity, and this activation depends on its RNA-binding domain. Here we investigated whether endogenous RNA triggers PKR activation in response to lipid exposure. Our results indicate that snoRNAs (smal...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-66540 | biostudies-arrayexpress
UnknownNucleolar stress induces nucleolar stress body formation via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans.
Not available
S-EPMC11343841 | biostudies-literature
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