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ProteomicsNucleophosmin sustains WNT-driven cell proliferation and tumour initiation in vivo
Nucleophosmin (NPM1) is a nucleolar protein frequently mutated in haematopoietic malignancies and overexpressed in many solid tumours, but little is known about its functional role in carcinogenesis. Here, we identify NPM1 as a commonly upregulated gene following APC loss in tissues that positively ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD062969 | Pride
Nucleophosmin Wnt signalling Tmt16plex Colorectal cancer 
TranscriptomicsGene expression profiling in acute myeloid leukemia with mutated NPM
Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of Nucleophosmin (NPMc+ AML), consequent to mutations in the NPM putative nucleolar localization signal. These events are mutually exclusive with the major AML-associated chromosomal rea...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-34860 | biostudies-arrayexpress
GenomicsChromatin localization of nucleophosmin determines the sorting and compartmentalization of ribosome biogenesis
Chromatin localization of nucleophosmin determines the sorting and compartmentalization of ribosome biogenesis
PRJNA657039 | ENA
GenomicsNucleophosmin supports WNT-driven hyperproliferation and tumour initiation
Nucleophosmin supports WNT-driven hyperproliferation and tumour initiation
PRJNA1335271 | ENA
TranscriptomicsMicroRNA profiling of human acute myeloid leukemia samples from patients characterized for subcellular localization/mutation status of NPM1 and FLT3 mutations
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML and shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs of 19-25 nucleotides in length that have been ...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-TABM-429 | biostudies-arrayexpress
TranscriptomicsMutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
Comparison of gene expression profiles of mouse bone marrow nucleated cells. All comparisons are made between biological replicates (different mice) derived from animals carrying the Type A cytoplasmic Nucleophosmin mutation (Npm1c) found in human Acute Myeloid Leukaemia. Mice were culled 8 weeks af...
ORGANISM(S): Mus musculus 
2011-03-15 | E-MEXP-3113 | biostudies-arrayexpress
GenomicsNucleophosmin sustains WNT-driven cell proliferation and tumor initiation in vivo
Nucleophosmin sustains WNT-driven cell proliferation and tumor initiation in vivo
PRJNA1051495 | ENA
TranscriptomicsEffect of ALK kinase inhibitor, ceritinib, on the gene expression profile of SUDHL-1 cell line
Tyrosine kinase receptor anaplastic lymphoma kinase (ALK) is physiologically expressed during embryogenesis. However, chromosomal rearrangements, especially translocations, cause expression of pathogenic ALK fusion proteins that drive tumor formation and maintenance. For instance, the translocation ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-15866 | biostudies-arrayexpress
TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
GenomicsChromatin localization of nucleophosmin determines the sorting and compartmentalization of ribosome biogenesis
Assembly of eukaryotic ribosomes begins in the nucleolus, a compartmentalized membraneless organelle. Although the two ribosomal subunits, 40S and 60S, assemble independently, it remains unknown if these particles are physically sorted as they assemble and how they partition from the central chromat...
ORGANISM(S): Schizosaccharomyces pombe 
2023-03-01 | GSE156203 | GEO
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