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TranscriptomicsNucleoredoxin is required for the maintenance of Wnt/β-catenin signaling in mice embryo
We previously showed that nucleoredoxin (NRX) suppresses Wnt/β-catenin signaling through its binding to Dishevelled (Dvl) (Nat Cell Biol 8, 501-508 (2006)). To clarify the in vivo role of NRX in mammals, we here generate NRX gene-knockout mice (NRX-/- mice) by homologous recombination. NRX-/- mice ...
ORGANISM(S): Mus musculus 
2010-10-26 | E-GEOD-21954 | biostudies-arrayexpress
ProteomicsProtein expression and oxidation in the hippocampus of neuronal nucleoredoxin knockout (Nestin-NXN-/-) versus floxed control mice (NXN-flfl)
Nucleoredoxin (NXN) is a thioredoxin-like member of the large group of redoxins which maintain redox balances in the cell. Its primary localization is the cytoplasm, and it is highly expressed in neurons. It has been described as a redox regulator of WNT signaling via maintenance of the redox balanc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024624 | Pride
Lc-ms/ms Hippocampus Redoxin Oxidoreductase Nucleoredoxin 
GenomicsNucleoredoxin enhances stem cell transition to pituitary hormone-producing cells
Nucleoredoxin enhances stem cell transition to pituitary hormone-producing cells
PRJNA1185705 | ENA
UnknownNucleoredoxin regulates WNT signaling during pituitary stem cell differentiation.
Not available
S-EPMC11838423 | biostudies-literature
UnknownNucleoredoxin regulates WNT signaling during pituitary stem cell differentiation.
Not available
S-EPMC12056309 | biostudies-literature
UnknownNucleoredoxin guards against oxidative stress by protecting antioxidant enzymes.
Not available
S-EPMC5547615 | biostudies-literature
TranscriptomicsNucleoredoxin enhances stem cell transition to pituitary hormone-producing cells
Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways in a redox-dependent manner. It is involved in a variety of cellular processes. Rare NXN mutations are reported in some individuals with recessive Robinow syndrome, whi...
ORGANISM(S): Mus musculus 
2025-01-27 | GSE281783 | GEO
UnknownNucleoredoxin-Dependent Targets and Processes in Neuronal Cells.
Not available
S-EPMC6280245 | biostudies-literature
UnknownReduced exploratory behavior in neuronal nucleoredoxin knockout mice.
Not available
S-EPMC8254043 | biostudies-literature
UnknownNucleoredoxin promotes adipogenic differentiation through regulation of Wnt/β-catenin signaling.
Not available
S-EPMC4306684 | biostudies-literature
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