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TranscriptomicsRiboMeth-seq: High-throughput mapping of ribose methylations in RNA at single-nucleotide resolution
The major information-carrying macromolecules in the cell, DNA, RNA, and protein, carry an additional layer of information on top of their sequence in the form of modifications of residues. The modifications provide additional functional groups and impact the structure and function of the molecules....
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-24 | E-GEOD-54655 | biostudies-arrayexpress
TranscriptomicsSnapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution
Ribosome assembly in eukaryotes involves the activity of hundreds of assembly factors that direct the hierarchical assembly of ribosomal proteins and numerous ribosomal RNA folding steps. However, detailed insights into the function of assembly factors and ribosomal RNA folding events are lacking. T...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-14 | E-GEOD-52878 | biostudies-arrayexpress
ProteomicsEukaryotic translation is modulated by natural mRNA nucleotide derivatives
RNA modifications are crucial factors for efficient protein synthesis. All classes of RNAs that are involved in translation are modified to different extents. Recently, mRNA modifications and their impact on gene regulation became a focus of interest because they can exert a variety of effects on th...
ORGANISM(S): Homo sapiens (Human) 
2019-01-30 | PXD011860 | Pride
Translation elongation Ribosome Decoding Biological Nucleotide modifications 
TranscriptomicsGenome-wide variation of cytosine modifications between European and African populations and the implications for complex traits
Elucidating cytosine modification difference between human populations can enhance our understanding of ethnic specificity in complex traits such as disease predisposition and drug response. In this study, cytosine modification levels in 133 HapMap lymphoblastoid cell lines (LCLs) derived from indiv...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-39672 | biostudies-arrayexpress
TranscriptomicsEpigenetic modifications and their relationships to smRNA and mRNA transcriptomes in maize
Genome-wide and organ-specific landscapes of epigenetic modifications and their relationships to mRNA and smRNA transcriptomes in maize We report an integrated genome-wide analysis of DNA methylation, histone modifications, smRNAs and mRNA transcriptional activity, using maize as a model. We surveye...
ORGANISM(S): Zea mays 
2009-04-27 | E-GEOD-15286 | biostudies-arrayexpress
UnknownNanopore detection of single-nucleotide RNA mutations and modifications with programmable nanolatches.
Not available
S-EPMC12534182 | biostudies-literature
ProteomicsNucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei
In Trypanosoma brucei, there are fourteen enzymatic biotransformations that collectively convert glucose into five essential nucleotide sugars: UDP-Glc, UDP-Gal, UDP-GlcNAc, GDP-Man and GDP-Fuc. These biotransformations are catalyzed by thirteen discrete enzymes, five of which possess putative perox...
ORGANISM(S): Trypanosoma brucei 
2021-01-28 | PXD023124 | Pride
Nucleotide sugar biosynthesis Glycosome localization T. brucei 
UnknownNew bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA.
Not available
S-EPMC1800513 | biostudies-literature
UnknownNucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code.
Not available
S-EPMC4737146 | biostudies-literature
UnknownNucleotide modifications in three functionally important regions of the Saccharomyces cerevisiae ribosome affect translation accuracy.
Not available
S-EPMC2794176 | biostudies-literature
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