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UnknownBinding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Not available
S-EPMC5775257 | biostudies-literature
ProteomicsATXN2L interacts mainly with NUFIP2, ATXN2L-absence causes NUFIP2 depletion, and ATXN2-polyQ expansion triggers NUFIP2 accumulation (proteome profiles)
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis. Ataxin-2-like (ATXN2L) is preferentially nuclear, more abundant, essent...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD061048 | Pride
Ataxin-2 
ProteomicsATXN2L interacts mainly with NUFIP2, ATXN2L-absence causes NUFIP2 depletion, and ATXN2-polyQ expansion triggers NUFIP2 accumulation (Co-IPs)
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis. Ataxin-2-like (ATXN2L) is preferentially nuclear, more abundant, essent...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD061161 | Pride
Atxn2l 
ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
GenomicsDHT alleviates neuroinflammation to reduce PND occurrence in aged mice via mmu_circ_0001442/miR-125a-3p/NUFIP2 axis
DHT alleviates neuroinflammation to reduce PND occurrence in aged mice via mmu_circ_0001442/miR-125a-3p/NUFIP2 axis
PRJNA891714 | ENA
TranscriptomicsshRNA RNA-seq from HepG2 (ENCSR584JRB)
RNA-seq on HepG2 cells treated with an shRNA knockdown against NUFIP2. (NUFIP2_BGHLV26) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2016-11-08 | GSE88374 | GEO
TranscriptomicsshRNA RNA-seq from K562 (ENCSR754RJA)
RNA-seq on K562 cells treated with an shRNA knockdown against NUFIP2. (NUFIP2_BGKLV34) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2016-11-08 | GSE88511 | GEO
UnknownStress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage.
Not available
S-EPMC9533235 | biostudies-literature
UnknownComprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.
Not available
S-EPMC4598758 | biostudies-literature
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