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ProteomicsConditional ATXN2L-nConditional ATXN2L-null in adult frontal cortex CamK2a+ neurons does not cause cell death, but restricts spontaneous mobility, and affects the alternative splicing pathway
Ataxin-2-like (ATXN2L) protein is required to survive embryonic development, as documented in mice with constitutive absence of ATXN2L Lsm, LsmAD and PAM2 domains, due to knockout (KO) of exons 5-8 with frameshift. Its less abundant paralog Ataxin-2 (ATXN2) has an extended N-terminus, where a polygl...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD064497 | Pride
Mrpl14 Srsf11 Stress granules Poly(a)-binding protein Naa38 Rps3 Label-free mass spectrometry Nsun2 Open field locomotion Ribonucleoproteins 
ProteomicsATXN2L interacts mainly with NUFIP2, ATXN2L-absence causes NUFIP2 depletion, and ATXN2-polyQ expansion triggers NUFIP2 accumulation (Co-IPs)
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis. Ataxin-2-like (ATXN2L) is preferentially nuclear, more abundant, essent...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD061161 | Pride
Atxn2l 
ProteomicsATXN2L interacts mainly with NUFIP2, ATXN2L-absence causes NUFIP2 depletion, and ATXN2-polyQ expansion triggers NUFIP2 accumulation (proteome profiles)
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis. Ataxin-2-like (ATXN2L) is preferentially nuclear, more abundant, essent...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-15 | PXD061048 | Pride
Ataxin-2 
UnknownMid-Gestation lethality of Atxn2l-Ablated Mice.
Not available
S-EPMC7404131 | biostudies-literature
UnknownATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance.
Not available
S-EPMC6382779 | biostudies-literature
UnknownFusion of the genes ataxin 2 like, ATXN2L, and Janus kinase 2, JAK2, in cutaneous CD4 positive T-cell lymphoma.
Not available
S-EPMC5732765 | biostudies-literature
UnknownConditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death but Restricts Spontaneous Mobility and Affects the Alternative Splicing Pathway.
Not available
S-EPMC12524157 | biostudies-literature
TranscriptomicsCRISPR RNA-seq from K562 (ENCSR585UBH)
RNA-seq on K562 cells treated with a CRISPR gRNA against ATXN2L. (ATXN2L-BGKcLV26) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2022-12-04 | GSE219459 | GEO
TranscriptomicsCRISPR RNA-seq from HepG2 (ENCSR234UAM)
RNA-seq on HepG2 cells treated with a CRISPR gRNA against ATXN2L. (ATXN2L-BGHcLV29-B) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2022-12-04 | GSE219606 | GEO
ProteomicsAffinity-purified interactants of reovirus muNS
Mammalian orthoreovirus (reovirus) nonstructural protein μNS nucleates viral factories (VFs), which are sites of viral genome replication, protein synthesis, and particle assembly. Reovirus mRNAs are not polyadenylated, yet these transcripts are efficiently translated. To identify host factors assoc...
ORGANISM(S): Mammalian orthoreovirus 3 Dearing Homo sapiens (Human) 
2025-11-24 | PXD069183 | Pride
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