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MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
MetabolomicsBasic Metabolism Studies (wt and TPA null)
Not available
ORGANISM(S): Mus musculus 
ST000160 | MetabolomicsWorkbench
TranscriptomicsExpression data from ozone-treated wild-type and G-protein null mutant Arabidopsis lines
Ozone pollution decreases plant growth and yield worldwide. Some of the effects are genetically-mediated and are reported to involve G-protein signaling pathways. Effects of ozone on gene expression were examined in wild-type and G-protein null mutants to determine affected genes and to determine ...
ORGANISM(S): Arabidopsis thaliana 
2011-12-24 | E-GEOD-34667 | biostudies-arrayexpress
GenomicsRNAseq expression of p53-null and p53-null/PLK2-null mammary tumors
RNAseq expression of p53-null and p53-null/PLK2-null mammary tumors
PRJNA731110 | ENA
TranscriptomicsDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
MEN1 is a tumor suppressor gene loss of which causes lipoma (fatty tumors under the skin) and many other endocrine and non-endocrine tumors. It's target genes in fat cells (adipocytes) are unknown. Gene expression in adipocytes that were in vitro differentiated from mouse embryonic stem cells (mES...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-65859 | biostudies-arrayexpress
TranscriptomicsPri-miRNA identification by generating a Drosha null/conditional-null mouse model.
We report the ability of the Drosha null/conditional-null mouse model to enable the identification of pri-miRNA transcripts. The conditional-null allele of Drosha phenocopies the null allele both in mESC and in mice, upon conversion to the null state with Cre. Examination of the effects of Drosha de...
ORGANISM(S): Mus musculus 
2015-02-09 | E-GEOD-55735 | biostudies-arrayexpress
TranscriptomicsExpression profiles of dnaA null, rok null, and dnaA null; rok null mutants
To identify potential targets of co-regulation by DnaA and Rok, we compared the transcriptional profiles of dnaA null, rok null, and dnaA null rok null mutants. Because a dnaA null mutant requires an oriC- strain background, we used an oriC- oriN+ background for all strains, to allow direct compari...
ORGANISM(S): Bacillus subtilis 
2015-06-13 | E-GEOD-69788 | biostudies-arrayexpress
ProteomicsTriple Null, a soybean bred to lack major seed allergen P34 and bioactive lectin and kunitz trypsin inhibitor
Seeds, including soybean (Glycine max), contain bioactive proteins with anti-nutritional and immunological properties that affect metabolism and assimilation of seed derived nutrients and as allergens that can induce escalating adverse immune responses. The presence of anti-nutritional proteins requ...
ORGANISM(S): Glycine max 
2022-02-23 | PXD000967 | Pride
Null Seed Soybean Allergen 
TranscriptomicsCX43 KO vs WT cortical astrocytes
RNA samples extracted from astrocytes cultured from wild type and Cx43 null neonatal mice were dye labeled and individually co-hybridized with a reference of labeled cDNAs pooled from a variety of tissues on eight gene arrays containing 8975 mouse DNA sequences
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-580 | biostudies-arrayexpress
TranscriptomicsGene Expression of ApoE Null and ApoE Null/RAGE Diabetic and Non-diabetic Mice
The multi-ligand Receptor for AGE (RAGE) contributes to atherosclerosis in apolipoprotein (ApoE) null mice in both the non-diabetic and diabetic states. Previous studies using soluble RAGE, the extracellular ligand-binding domain of RAGE, or homozygous RAGE null mice showed that blockade or deletion...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-15729 | biostudies-arrayexpress
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