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MetabolomicsComparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

BACKGROUND: Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development. Der p 1 allergen from house dust mite is a...

2023-08-22 | MTBLS1755 | MetaboLights
TranscriptomicsTranscription profiling of human airway epithelial cells before and after segmental allergen challenge to identify effects of allergen challenge on airway epithelial cell gene expression
Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and change...
ORGANISM(S): Homo sapiens 
2007-11-21 | E-GEOD-3004 | biostudies-arrayexpress
ProteomicsAllergen marker discovery and quantification
We developed a high-resolution accurate mass (HRAM)-LC-MS/MS method using the same food extract used in the ELISA method and an MS sample preparation kit. Multiple food allergen analysis was performed using 1, 5, 10, and 20 ppm of allergen-incurred processed foods. Overall, a strong correlation was ...
ORGANISM(S): Cellular Organisms 
2024-07-31 | PXD053465 | JPOST Repository
ProteomicsIntegrating Proteomes for Lung Tissue and Lavage Reveals Pathways that Integrate Responses in Allergen-Challenged Mice
To capture interplay between biological pathways we analyzed the proteome from matched lung tissue and bronchoalveolar lavage fluid (BALF) of individual allergen-naive and house dust mite (HDM)-challenged BALB/c mice, a model of allergic asthma. Unbiased label-free LC-MS/MS analysis quantified 2,675...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-08-24 | MSV000086003 | MassIVE
ProteomicsDelineation of the olive pollen proteome: A focus on its allergen families
The delineation of the olive pollen proteome and its allergogram can improve the clinical management of patients with this pollinosis. We here integrated the recently described wild olive genomic data in a comprehensive proteomic approach to get the annotated olive (Olea europaea) pollen proteome an...
ORGANISM(S): Olea europaea (Common olive) 
2019-06-17 | PXD012279 | Pride
Allergen families Proteome Olive pollen 
TranscriptomicsExpression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (ER and DR)
To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge between early responders (ERs) and dual responders (DRs) following allergen inhalation challenge Blood was collected immediately prior to, and two hours after challenge The...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-40240 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bronchial epithelial cell line H292 exposed to allergen reveals a possible role for TNF-I?
Response to allergen was studied in bronchial epithelial cell line H292. Cells were cultured and subsequently exposed to House dust mite or vessel (saline); Microarray data was analysed using bioinformatics and biostastics. We find a strong response to allergen in epithelial cells Experiment Overall...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9151 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Allergen-stimulated CD4+ T cells from hens egg allergic patients
Allergen-stimulated T cells from hen’s egg-allergic children were analyzed to identify genes that are specifically up-regulated in these cells. Experiment Overall Design: PBMCs from three hen’s egg allergic children and two non-allergic children were cultured in RPMI 1640 supplemented with 10% a...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7512 | biostudies-arrayexpress
TranscriptomicsSputum cell gene expression following allergen challenge
Sputum cells collected before (visit 2) and after (visit 4) allergen challenge in asthma patients were isolated and RNA purified for analysis on gene expression arrays. Human subject recruitment part of NIH sponsored protocol as part of the Eosinophil Program Project Grant (PI: Dr. Nizar Jarjour) Sp...
ORGANISM(S): Homo sapiens 
2013-04-20 | E-GEOD-46238 | biostudies-arrayexpress
ProteomicsAllergen detection in commercial foods
The frequent use of precautionary food allergen labeling statements such as “may contain” poses challenges to allergic individuals relying on such labeling to determine whether a food is safe to consume. To survey the frequency at which these precautionary statements indicate allergen contamination ...
ORGANISM(S): Bertholletia excelsa Fagopyrum esculentum Sesamum indicum Glycine max Anacardium occidentale Arachis hypogaea (Peanut) Prunus dulcis Hordeum vulgare (Barley) Carya illinoinensis Gallus gallus (Chicken) Pistacia vera Avena sativa Bos taurus (Bovine) Corylus avellana Juglans Triticum aestivum (Wheat) Secale cereale Sinapis alba Apium graveolens Lupinus angustifolius 
2019-07-17 | PXD007688 | Pride
Allergen Ige Allergy Food 
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