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ProteomicsProteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms
Ultraviolet (UV)-induced DNA lesions threaten genomic stability and are associated with skin carcinogenesis. These lesions are primarily repaired by the nucleotide excision repair (NER) pathway. However, alternative repair mechanisms and regulators are emerging as critical contributors to managing U...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD061212 | Pride
Uv Uv Dek Numa1 Dna damage 
UnknownNuMA1 promotes axon initial segment assembly through inhibition of endocytosis.
Not available
S-EPMC7041696 | biostudies-literature
GenomicsMBNL1-dependent alternative splicing of NUMA1 shapes neuronal identity during fibroblast-to-neuron reprogramming
MBNL1-dependent alternative splicing of NUMA1 shapes neuronal identity during fibroblast-to-neuron reprogramming
PRJNA1406691 | ENA
TranscriptomicsMBNL1-dependent alternative splicing of NUMA1 shapes neuronal identity during fibroblast-to-neuron reprogramming
Direct neuronal reprogramming provides a powerful strategy to generate neurons from somatic cells without passing through a pluripotent state. However, the post-transcriptional mechanisms that refine neuronal identity downstream of fate induction remain poorly understood. Here, we identify alternati...
ORGANISM(S): Homo sapiens 
2026-06-15 | GSE317293 | GEO
UnknownProteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms.
Not available
S-EPMC12644609 | biostudies-literature
UnknownGlobal Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation.
Not available
S-EPMC6316800 | biostudies-literature
UnknownA genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition.
Not available
S-EPMC7188281 | biostudies-literature
UnknownLEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer.
Not available
S-EPMC12537492 | biostudies-literature
TranscriptomicsRNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons [RNA-seq]
RNA helicase MOV10 is highly expressed in postnatal brain and associates with FMRP and AGO2, suggesting a role in translation regulation in learning and memory. We generated a brain-specific knockout mouse (Mov10 Deletion) with greatly reduced MOV10 expression in cortex and hippocampus. Behavior tes...
ORGANISM(S): Mus musculus 
2024-10-04 | GSE232771 | GEO
TranscriptomicsRNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons [eCLIP-seq]
RNA helicase MOV10 is highly expressed in postnatal brain and associates with FMRP and AGO2, suggesting a role in translation regulation in learning and memory. We generated a brain-specific knockout mouse (Mov10 Deletion) with greatly reduced MOV10 expression in cortex and hippocampus. Behavior tes...
ORGANISM(S): Mus musculus 
2024-10-04 | GSE278282 | GEO
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