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GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
ProteomicsStoichiometry of Nucleosome Remodelling and Deacetylase (NuRD) complex
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to detailed analysis because of its low abundance and resistance to recombinant production. As part of a larger project, absolute quantification using isotopically-labelle...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-01-08 | PXD010110 | Pride
Quantitative ms Nurd Aqua 
ProteomicsComparison of the composition and interaction partners of the Nucleosome Remodeling and Deacetylase (NuRD) complex in cancer cells
The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for normal development in metazoans and has direct implications in a range of human diseases. Amongst all classes of chromatin remodeling complexes, the NuRD complex has been the most recalcitrant to analysis. This is, in part, du...
ORGANISM(S): Homo sapiens (Human) 
2019-03-13 | PXD012061 | Pride
Shotgun proteomics Ibaq Stoichiometry Nurd Interactome 
TranscriptomicsControl of neural specification programmes by the NuRD complex
Apical progenitors from wild type and NestinCre:Mbd3Flox/Flox embryos at E12.5, E14.5 and E16.5 were used for gene expression microarray analyses to identify gene expression changes dependent upon a functional NuRD complex.
ORGANISM(S): Mus musculus 
2015-12-12 | E-MTAB-1332 | biostudies-arrayexpress
GenomicsTranscription factor binding and epigenetic modifications during NuRD complex induction
Molecular functions of the Nucleosome Remodeling and Deacetylation (NuRD) complex in the control of gene expression were investigated using an inducible system to direct its assembly in embryonic stem cells. This dataset maps time-resolved DNA association of NuRD complex members, pluripotency factor...
ORGANISM(S): Mus musculus 
2018-05-31 | E-MTAB-6804 | biostudies-arrayexpress
ProteomicsUnique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex
The combination of four proteins and their paralogues including MBD2/3, GATAD2A/B, CDK2AP1, and CHD3/4/5, which we refer to as the MGCC module, form the chromatin remodeling module of the Nucleosome Remodeling and Deacetylase (NuRD) complex. To date, mechanisms by which the MGCC module acquires para...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025263 | Pride
Chahp complex Mass spectrometry Chromatin remodeling Ncor complex Protein-protein interactions Nurd complex Aggregation protein region 
GenomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-888 | biostudies-arrayexpress
TranscriptomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-889 | biostudies-arrayexpress
ProteomicsThe NuRD complex is required for Thpok-mediated CD4+ T cell development
This data represent characterization of the interactome of murine Thpok. A version of Thpok (Thpok-Bio) subject to biotinylation in vivo by the BirA biotin ligase was used; to assess Thpok interactions in primary cells, Thpok-Bio was retrovirally expressed in in vitro activated CD4+ T cells from Thp...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088126 | MassIVE
TranscriptomicsNucleosome occupancy during NuRD complex induction
Molecular functions of the Nucleosome Remodeling and Deacetylation (NuRD) complex in the control of gene expression were investigated using an inducible system to direct its assembly in embryonic stem cells. This dataset identifies genome-wide changes in nucleosome positioning at sites of NuRD assoc...
ORGANISM(S): Mus musculus 
2018-05-31 | E-MTAB-6807 | biostudies-arrayexpress
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