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GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of MYC+ and MYC- mouse Germinal Center B cells
Germinal centers (GC) arise within B cell follicles upon antigenic challenge. In the dark zones (DZ) of GCs, B cells proliferate and hypermutate their immunoglobulin genes, and mutants with increased affinity are positively selected in the light zone (LZ) to either differentiate into plasma and memo...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-38304 | biostudies-arrayexpress
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
UnknownAmino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation.
Not available
S-EPMC3028632 | biostudies-literature
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
UnknownPotential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.
Not available
S-EPMC5854441 | biostudies-literature
UnknownIdentification of chromosomal translocation hotspots via scan statistics.
Not available
S-EPMC4155254 | biostudies-literature
UnknownOptimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection.
Not available
S-EPMC4814126 | biostudies-literature
UnknownThe proto-oncogene MYC is required for selection in the germinal center and cyclic reentry.
Not available
S-EPMC3711534 | biostudies-literature
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