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TranscriptomicsExpression data from human sarcoma patient samples treated with either vehicle control or Nutlin-3a
This study has examined the molecular mechanisms underlying sensitivity of sarcomas to Nutlin-3a, a non-genotoxic activator of the p53 pathway. Human patient material was collected immediately following surgical resection, dissected into small pieces and ex planted onto gelatin sponges immersed in m...
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-48296 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human multiple myloma p53 wild type cells treated with nutlin 3A
The miRNA profiles were analyzed for nutlin 3A treated and untreated multiple myloma p53 wild type cells
ORGANISM(S): Homo sapiens 
2010-07-22 | E-TABM-1038 | biostudies-arrayexpress
GenomicsATAC-seq from Nutlin-3a-treated MCF-7 cells
ATAC-seq from Nutlin-3a-treated MCF-7 cells
PRJNA1051614 | ENA
ProteomicsTranscriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes
Transcriptomic analyses revealed hundreds of p53-regulated genes, however these studies used a limited number of cell lines and p53-activating agents. Therefore, we searched for candidate p53-target genes by employing stress factors and cell lines never used in high-throughput search for p53-regulat...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD036860 | Pride
Transcriptome Secretome P53  innate immunity  wnt signaling 
GenomicsNutlin-3a induced changes in the transcriptome of MCF-7 cells
Nutlin-3a induced changes in the transcriptome of MCF-7 cells
PRJNA895053 | ENA
GenomicsNanopore long-read sequencing from Nutlin-3a-treated MCF-7 cells
Nanopore long-read sequencing from Nutlin-3a-treated MCF-7 cells
PRJNA938478 | ENA
GenomicsQuantSeq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells
QuantSeq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells
PRJNA926620 | ENA
TranscriptomicsDiscovery of the p53 targetome in MCF7 cells from RNA-seq data
RNA-seq and ChIP-seq on MCF-7 breast cancer cell line upon activation of p53 by the non-genotoxic small molecule Nutlin-3a RNA-seq on MCF7 without (NS) or with Nutlin-3a stimulation (S), in duplicate, using illumina HiSeq 2000
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-47042 | biostudies-arrayexpress
GenomicsCAGE-seq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells
CAGE-seq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells
PRJNA926621 | ENA
GenomicsCUT&Tag of H3K4me1 and H3K27ac from Nutlin-3a-treated MCF-7 cells
CUT&Tag of H3K4me1 and H3K27ac from Nutlin-3a-treated MCF-7 cells
PRJNA1165248 | ENA
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