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MetabolomicsMulti-Omics Reveals that Alkaline Mineral Complex Enhances Nutrient Digestion–Absorption and Gut Health

This study, conducted under a high-concentrate finishing context, used an integrated multi-omics approach to evaluate the effects of an Alkaline Mineral Complex (AMC) on jejunal digestion–absorption and gut health in beef cattle. The results showed that AMC alleviated mucosal pathological injury ...

2026-07-14 | MTBLS13175 | MetaboLights
MetabolomicsInositol polyphosphates regulate resilient mechanisms in the green alga Chlamydomonas reinhardtii to adapt to extreme nutrient conditions

In the actual context of climate changing environments, photosynthetic organisms need to adapt to more extreme conditions. Microalgae can be excellent organisms to understand molecular mechanisms that activate survival mechanisms under stress. Chlamydomonas reinhardtii signaling mutants are extre...

2024-12-05 | MTBLS10779 | MetaboLights
ProteomicsPhosphoproteomics of Arabidopsis seedlings under carbon/nitrogen-nutrient stress
Nutrient availability, in particular that of carbon (C) and nitrogen (N), is one of the most important factors for the regulation of plant metabolism and development. In addition to independent utilization, the ratio of C to N metabolites in the cell is also important for the regulation of plant gro...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2020-03-16 | PXD016507 | JPOST Repository
MetabolomicsFrom maternal metabolome to placental development: thiamine-driven placental Notch-PI3K/AKT pathway coordinates placental angiogenesis and nutrient transport
Maternal supplementation with thiamine during gestation and lactation promotes placental development and enhances offspring growth through activation of the Notch signaling pathway.
2025-07-30 | MTBLS12796 | MetaboLights
TranscriptomicsNutrient-Regulated Antisense and Intragenic RNAs Modulate a Signal Transduction Pathway
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO-system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of genes (PHO genes) is expressed to activate phosp...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-23 | E-GEOD-13350 | biostudies-arrayexpress
ProteomicsProximity-biotinylation (BioID) to dissect cytoplasmic p53 signaling networks under nutrient stress
p53 signaling is a major response mechanism to cellular stresses through cytoplasmic or nuclear action. While p53 protein levels have been shown to increase upon nutrient stresses such as starvation, the exact signaling cascade in this context remains elusive. Here, we use proximity biotinylation (B...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027734 | Pride
Nutrient stress Starvation P53 signaling Bioid Interactome 
TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
ProteomicsProfiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling
Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-06-17 | MSV000083988 | MassIVE
TranscriptomicsHit-and-run transcriptional control by bZIP1 mediates rapid nutrient signaling in Arabidopsis
To identify potential transient interactions between a TF and its targets, we developed an approach that can identify primary targets based either on TF-induced regulation or TF-binding, assayed in the same samples. Our studies focused on the TF bZIP1 (BASIC LEUCINE ZIPPER 1), a central integrator o...
ORGANISM(S): Arabidopsis thaliana 
2014-06-23 | E-GEOD-54049 | biostudies-arrayexpress
TranscriptomicsDynamic Expression of Imprinted Genes Associates with Maternally Controlled Nutrient Allocation during Maize Endosperm Development
In angiosperms, the endosperm provides nutrients for embryogenesis or seed germination and is the primary tissue where gene imprinting occurs. To map the imprintome of the early developing endosperm in maize, we performed high-throughput transcriptome sequencing of the kernels at 0, 3, 5 days after ...
ORGANISM(S): Zea mays 
2013-06-29 | E-GEOD-48425 | biostudies-arrayexpress
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