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TranscriptomicsThe miR-155/PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation [RNA-Seq]
miR-155 inhibits PU.1 expression, leading to the initiation of the initiation of plasma cell differentiation pathway. Additional PU.1 targets include a network of genes whose products are involved in adhesion, with direct links to B:T interactions. Sequencing analysis of B cell transcriptome using I...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-61425 | biostudies-arrayexpress
GenomicsThe miR-155/PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation [ChIP-Seq]
miR-155 inhibits PU.1 expression, leading to the initiation of the initiation of plasma cell differentiation pathway. Additional PU.1 targets include a network of genes whose products are involved in adhesion, with direct links to B:T interactions. Sequencing analysis of PU.1 binding in B cells usin...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-61424 | biostudies-arrayexpress
TranscriptomicsBlimp1 controls plasma cell physiology and function
Antibody-secreting plasma cells are the terminal stage of the B-cell lineage. Plasma cell differentiation requires a major resetting of gene expression to silence the B cell transcriptional program, whilst establishing secretory function and long-term survival. The transcription factors Blimp1 and I...
ORGANISM(S): Mus musculus 
2016-01-18 | E-GEOD-70981 | biostudies-arrayexpress
TranscriptomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells [RNA-seq]
We demonstrate that transcription factor IRF4 is induced in a T cell receptor (TCR) affinity-dependent manner and functions as a dose-dependent regulator of the metabolic function of activated T cells. IRF4 regulates the expression of key molecules required for aerobic glycolysis of effector T cells...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49929 | biostudies-arrayexpress
GenomicsThe transcription factor IRF4 is essential for T cell receptor affinity mediated metabolic programming and clonal expansion of T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-49931 | biostudies-arrayexpress
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