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TranscriptomicsSelective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
The nuclear phase of the gene expression pathway culminates in the export of mature mRNAs to the cytoplasm through nuclear pore complexes (NPCs). GANP (Germinal-centre Associated Nuclear Protein) promotes the transfer to NPCs of mRNAs bound to the transport factor NXF1. Here, we demonstrate that GAN...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-54481 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of export factors in Drosphila Schneider cell lines
Six different endogenous Drosophila proteins (all potential export factors) have been inactivated using RNAi and leptomycin B (LMB) treatments. Five different endogenous Drosophila proteins (all potential export factors) have been targeted by RNAi. The effect on mRNA export is analyzed by monitoring...
ORGANISM(S): Drosophila melanogaster 
2003-05-15 | E-MEXP-4 | biostudies-arrayexpress
ProteomicsThe master energy homeostasis regulator PGC-1α couples transcriptional co-activation and mRNA nuclear export
PGC-1α plays a central role in maintaining the mitochondrial and energy metabolism homeostasis, linking external stimuli to the transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a serine/arginine-rich (RS) region and a putative RNA re...
ORGANISM(S): Homo sapiens (Human) 
2023-09-06 | PXD031189 | Pride
Tmt lc-msms Energy metabolism Mitochondria Gene expression Peroxisome proliferator-activated receptor gamma coactivator 1 alpha Nxf1-dependent mrna nuclear export 
GenomicsThe mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export
The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export
PRJNA482996 | ENA
TranscriptomicsThe mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export
Alternative polyadenylation (APA) produces mRNA isoforms with different 3’UTR lengths. Previous studied indicated that 3’ end processing and mRNA nuclear export are intertwined in gene regulation. Here, we show that mRNA export factors generally facilitate usage of distal cleavage and polyadenylatio...
ORGANISM(S): Homo sapiens 
2019-01-14 | GSE117701 | GEO
UnknownInner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export.
Not available
S-EPMC4787764 | biostudies-literature
TranscriptomicsSelective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
The nuclear phase of the gene expression pathway culminates in the export of mature mRNAs to the cytoplasm through nuclear pore complexes (NPCs). GANP (Germinal-centre Associated Nuclear Protein) promotes the transfer to NPCs of mRNAs bound to the transport factor NXF1. Here, we demonstrate that GAN...
ORGANISM(S): Homo sapiens 
2014-02-14 | GSE54481 | GEO
UnknownSUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.
Not available
S-EPMC11659784 | biostudies-literature
UnknownThe mRNA Export Receptor NXF1 Coordinates Transcriptional Dynamics, Alternative Polyadenylation, and mRNA Export.
Not available
S-EPMC6450743 | biostudies-literature
UnknownSelective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP.
Not available
S-EPMC4005691 | biostudies-literature
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