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TranscriptomicsHuman pluripotent stem cell-derived ROR1e lens epithelial cell single cell RNA-sequencing
Detailed transcriptomic analyses of differentiated cell populations derived from human pluripotent stem cells is routinely used to assess the identity and utility of the differentiated cells. In particular, single cell RNA-sequencing (scRNA-seq) can provide insights into both the cellular and transc...
ORGANISM(S): Homo sapiens 
2020-11-27 | E-MTAB-9178 | biostudies-arrayexpress
UnknownHistone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging.
Not available
S-EPMC7761391 | biostudies-literature
Unknown#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol.
Not available
S-EPMC8609898 | biostudies-literature
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
ProteomicsEtomoxir: A Promiscuous Fatty Acid Mimetic Chemoproteomic Probe
Etomoxir has been used for decades as a popular small molecule inhibitor of Carnitine Palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid b-oxidation. To test the specificity of etomoxir, we generated click chemistry enabled reagents to label etomoxir binding proteins in situ. Etomoxir b...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD051969 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsEtomoxir as a Promiscuous Chemoproteomic Probe.
Primary hepatocytes from WT or Pex5KO mouse livers were treated with 100uM clickable etomoxir analogues and the proteins bound to etomoxir were pulled down and identified. The small molecule inhibitor etomoxir has been used for many years as a specific inhibitor of Cpt1 but these data show that etom...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD045866 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
TranscriptomicsSingle-cell RNA-seq of primary human gastric interstitial cells of Cajal
Gastrointestinal (GI) motility disorders affect millions of people worldwide, yet remain poorly treated due to insufficient knowledge of the molecular networks controlling GI motility. Interstitial cells of Cajal (ICC) are critical GI pacemaker cells, and abnormalities in ICC are implicated in GI mo...
ORGANISM(S): Homo sapiens 
2022-07-04 | E-MTAB-9602 | biostudies-arrayexpress
UnknownEarly Care and Education Center Environmental Factors Associated with Product- and Process-Based Locomotor Outcomes in Preschool-Age Children.
Not available
S-EPMC8871663 | biostudies-literature
TranscriptomicsU87MG Decoded: The Genomic Sequence of a Cytogenetically Aberrant Human Cancer Cell Line
U87MG is a commonly studied grade IV glioma cell line that has been analyzed in at least 1,700 publications over four decades. In order to comprehensively characterize the genome of this cell line and to serve as a model of broad cancer genome sequencing, we have generated greater than 30x genomic s...
ORGANISM(S): Homo sapiens 
2010-01-24 | E-GEOD-19986 | biostudies-arrayexpress
UnknownCovalent Modification of p53 by (<i>E</i>)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one.
Not available
S-EPMC11555513 | biostudies-literature
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