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ProteomicsEtomoxir as a Promiscuous Chemoproteomic Probe.
Primary hepatocytes from WT or Pex5KO mouse livers were treated with 100uM clickable etomoxir analogues and the proteins bound to etomoxir were pulled down and identified. The small molecule inhibitor etomoxir has been used for many years as a specific inhibitor of Cpt1 but these data show that etom...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD045866 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsEtomoxir: A Promiscuous Fatty Acid Mimetic Chemoproteomic Probe
Etomoxir has been used for decades as a popular small molecule inhibitor of Carnitine Palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid b-oxidation. To test the specificity of etomoxir, we generated click chemistry enabled reagents to label etomoxir binding proteins in situ. Etomoxir b...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-04 | PXD051969 | Pride
Liver Fatty acid oxidation Cpt1 Etomoxir 
ProteomicsData in support of Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with Etomoxir or Interferon-beta
Multiple Sclerosis is a neurogenerative disease, where inflammation plays an essential role and the loss of tolerance for self produces proteins is a key feature. To investigate the autoimmune response, we use serum from experimental autoimmune encephalomyelitis (EAE) induced rats and investigate au...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-05-14 | PXD008835 | Pride
Multiple sclerosis Autoantibodies Experimental autoimmune encephalomyelitis Rat model Inflammation Autoantigens Etomoxir 
TranscriptomicsEffect on fatty acid oxidation by etomoxir and etomoxir plus beta-hydroxybutyrate in Glioma-derived Mesenchymal stem cells
The experiment was carried out in triplicates in untreated, etomoxir treated and etomoxir plus beta-hydroxybutyrate (3HB) treated conditions. MES83 (Glioma-derived Mesenchymal stem cells) were either untreated or treated with 40uM of etomoxir alone or in combination with 0.5mM of beta-hydroxybutyrat...
ORGANISM(S): Homo sapiens 
2020-03-31 | E-MTAB-8017 | biostudies-arrayexpress
UnknownEtomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.
Not available
S-EPMC6125190 | biostudies-literature
UnknownEtomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe.
Not available
S-EPMC11381838 | biostudies-literature
GenomicsGene-expression profiling in pancreatic cancer cells treated with macrophage conditioned media and etomoxir
Gene-expression profiling in pancreatic cancer cells treated with macrophage conditioned media and etomoxir
PRJNA559667 | ENA
GenomicsTranscriptome upon Mof deletion and Etomoxir treatment in ground-state mouse (m) ESCs
Transcriptome upon Mof deletion and Etomoxir treatment in ground-state mouse (m) ESCs
PRJNA564621 | ENA
TranscriptomicsscRNAseq of four syngeneic human melanoma cell lines (two replicate per cell line) to study mechanisms of resistance to the BRAF inhibitor vemurafenib
Three cell lines were derived from the A375 human melanoma (harbouring the BRAF v600e mutation; ATCC) after treatment with vemurafenib during a period of 4-5 weeks in the absence (MAPKi-resist Rep1/Rep2) or presence of the fatty acid oxidation inhibitors etomoxir (Etomoxir Rep1/Rep2) or ranolazine (...
ORGANISM(S): Homo sapiens 
2023-06-20 | E-MTAB-12412 | biostudies-arrayexpress
UnknownEtomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A<sub>2</sub> and mitochondrial respiration.
Not available
S-EPMC11402452 | biostudies-literature
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