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ProteomicsStructure of the Fanconi anaemia monoubiquitin ligase complex
The Fanconi Anemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks. Genetic inactivation of this pathway impairs development, prevents blood production and promotes cancer. The key molecular step in the FA pathway is the monoubiquitination of a heterodime...
ORGANISM(S): Gallus gallus (Chicken) 
2019-10-16 | PXD014282 | Pride
Fanconi anemia monoubiquitin ligase Human Crosslinking ms Em Electron microscopy Clms 
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
UnknownMetastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.
Not available
S-EPMC5019760 | biostudies-literature
UnknownMetastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update.
Not available
S-EPMC7504972 | biostudies-literature
UnknownAlterations in Somatic Driver Genes Are Associated with Response to Neoadjuvant FOLFIRINOX in Patients with Localized Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC9319357 | biostudies-literature
UnknownEarly-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.
Not available
S-EPMC8418394 | biostudies-literature
UnknownPerioperative Gemcitabine + Erlotinib Plus Pancreaticoduodenectomy for Resectable Pancreatic Adenocarcinoma: ACOSOG Z5041 (Alliance) Phase II Trial.
Not available
S-EPMC6868305 | biostudies-literature
UnknownIntegrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.
Not available
S-EPMC5287055 | biostudies-literature
UnknownGlobal, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer.
Not available
S-EPMC3716216 | biostudies-literature
UnknownGenomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC10073273 | biostudies-literature
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