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GenomicsOgt chromatin recruitment is mediated by TET proteins in mouse ES cells [ChIP-Seq]
These data include the genome wide location analysis of Ogt by ChIP of Ogt in mouse ES cells. Precipitation of formaldehyde cross-linked chromatin prepared from mouse ES cell using specific antibody against OGT and IgG as control.
ORGANISM(S): Mus musculus 
2013-01-06 | E-GEOD-39154 | biostudies-arrayexpress
TranscriptomicsExpression data from HEK293 cells with or without MIBP1 overexpression
The transcription factor c-MYC intron binding protein 1 (MIBP1) binds to various genomic regulatory regions, including intron 1 of c-MYC. This factor is highly expressed in post-mitotic neurons in the fetal brain and may be involved in various biological steps, such as neurological and immunological...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-26420 | biostudies-arrayexpress
GenomicsRegulation of mitophagy by O-linked N-acetylglucosamine transferase is essential for hematopoietic stem cell maintenance
Regulation of mitophagy by O-linked N-acetylglucosamine transferase is essential for hematopoietic stem cell maintenance
PRJNA478507 | ENA
ProteomicsQuantitative Proteomics Reveals that the OGT Interactome is Remodeled in Response to Oxidative Stress
The dynamic modification of specific serine and threonine residues of intracellular proteins by O-linked N-acetyl-β-D-glucosamine (O-GlcNAc) mitigates injury and promotes cytoprotection in a variety of stress models. The O-GlcNAc transferase (OGT) and the O-GlcNAcase (OGA) are the sole enzymes that ...
ORGANISM(S): Mus Musculus 
2021-04-05 | PXD021091 | panorama
TranscriptomicsConserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response
Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using w...
ORGANISM(S): Caenorhabditis elegans 
2015-05-01 | E-GEOD-53732 | biostudies-arrayexpress
GenomicsGenome wide binding sites of BAP1, HCF1 and OGT
We report the genome wide binding sites of BAP1, HCF1 and OGT in bone marrow derived macrophages. De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse ...
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-40723 | biostudies-arrayexpress
TranscriptomicsRegulation of mitophagy by O-linked N-acetylglucosamine transferase is essential for hematopoietic stem cell maintenance
O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes post-translational modification of target proteins by introducing O-GlcNAc moiety on serine or threonine residues. OGT critically regulates various cellular functions in many cell types. However, its roles in hematopoietic stem and ...
ORGANISM(S): Mus musculus 
2020-12-09 | GSE116433 | GEO
ProteomicsOGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis
TMT-based proteomic and phosphoproteomic analysis of mouse embryonic stem cells upon deletion of Ogt.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-16 | MSV000088393 | MassIVE
UnknownO-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension.
Not available
S-EPMC4390469 | biostudies-literature
UnknownExtracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease.
Not available
S-EPMC4050115 | biostudies-literature
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