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MetabolomicsOA-HOXB9-ODC1-Polyamine Axis Mediates Metabolic Syndrome Promoting Endometrial Cancer Progression

Metabolic syndrome (MS) is a risk factor for both the development and progression of endometrial cancer (EC); however, the mechanism remains unclear. We found that polyamine metabolites are significantly elevated in the sera and tumor tissues of EC patients with MS (ECWMS). Hyperlipidemia is a cr...

2025-11-08 | MTBLS13106 | MetaboLights
GenomicsCellvibrio sp. OA-2007
Cellvibrio sp. OA-2007 genome sequencing project
PRJDB3489 | ENA
ProteomicsProteomics profiling of human synovial fluid suggests global increased protein interplay in early-osteoarthritis (OA) and lost in late-stage OA
The underlying molecular mechanisms in osteoarthritis (OA) development are largely unknown. This study explores the proteome and the pairwise interplay of proteins on a global level in synovial fluid from patients with late-stage knee OA (arthroplasty), early knee OA (arthroscopy due to degenerative...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD023708 | Pride
Dia Synovial fluid Osteoarthritis 
TranscriptomicsMicroRNA expression profile in macrophages from rheumatoid arthritis and osteoarthritis patients
In osteoarthritis (OA) and rheumatoid arthritis (RA), many pathological alterations result from aberrant macrophage hyperactivation in the inflamed synovial membrane, and inhibition of macrophage effector functions is a therapeutic strategy in both diseases. Little is known, about the specific gene...
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-63745 | biostudies-arrayexpress
TranscriptomicsGene expression profiles from joint-matched macroscopically intact and OA affected cartilage of patients undergoing joint replacement surgery due to end-stage OA
Genome wide gene expression was determined in paired samples of OA affected and preserved cartilage of the same joint using microarray analysis for 33 patients of the RAAK-study. Among the 1717 genes that were significantly different expressed between OA affected and preserved cartilage we found sig...
ORGANISM(S): Homo sapiens 
2014-07-28 | E-GEOD-57218 | biostudies-arrayexpress
GenomicsStreptomyces kronopolitis strain:6G-OA-10
Streptomyces kronopolitis strain:6G-OA-10 Genome sequencing and assembly
PRJNA833308 | ENA
GenomicsStreptomyces ardesiacus strain:6G-OA-21
Streptomyces ardesiacus strain:6G-OA-21 Genome sequencing and assembly
PRJNA833309 | ENA
ProteomicsMSCs OA SILAC Mass spectrometry imaging
In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and metabolomic-associated molecular events during the chondrogenesis of MSCs could provide alternative...
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD012879 | Pride
Metabolites Proteins Imaging Mass spectrometry Ostearthritis 
TranscriptomicsCTL-OA-OP human IT PF Bone - CompuGen H19K microarray study
Aims of study: (1) To identify systemic differences in osteoarthritic (OA) bone that contribute to OA pathogenesis. (2) Identify novel osteoporotic (OP) bone-related disease genes. Study involved comparison of trabecular bone extracted from the intertrochanteric (IT) region of the proximal femur (PF...
ORGANISM(S): Homo sapiens 
2008-01-14 | E-GEOD-8406 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat experimental model of knee osteoarthritis
OBJECTIVE: To analyze genome-wide changes in chondrocyte gene expression in a surgically induced model of early osteoarthritis (OA) in rats, to assess the similarity of this model to human OA, and to identify genes and mechanisms leading to OA pathogenesis. METHODS: OA was surgically induced in 5 ra...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-8077 | biostudies-arrayexpress
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