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TranscriptomicsRNAi knock down of heterochromatin protein 1 in male and female Drosophila flies
Drosophila heterochromatin protein 1- HP1 is believed to be involved in active transcription, transcriptional gene silencing, and the formation of heterochromatin2-7. However, little is known about the function of HP1 during development. Using a Gal4-induced RNA interference system, we show that con...
ORGANISM(S): Drosophila melanogaster 
2007-08-01 | E-GEOD-3055 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of testis biopsies to investigate testis developmental gene expression in cryptorchid boys at risk of azoospermia
Despite timely and successful surgery, 32% of patients with bilateral and 10% with unilateral cryptorchidism will develop azoospermia. Cryptorchid boys at risk of azoospermia display a typical testicular histology of impaired mini-puberty at the time of the orchidopexy. During mini-puberty increased...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25518 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 cells
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on the proliferation and survival of these cells. We used microarray to understand the contribution of FGFR sig...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19220 | biostudies-arrayexpress
TranscriptomicsExpression data from TKI258 treated 4T1 tumors
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on 4T1 tumors in-vivo. We used microarray to understand the contribution of FGFR signaling to the tumor formati...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-19221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of EBV transformed fibroblasts vs untransformed to analyse DNA replication timing analysis of human chromosome 22 at high resolution and different developmental states
DNA replication timing analysis of human chromosome 22 at high resolution and different developmental states
ORGANISM(S): Homo sapiens 
2004-11-01 | E-MEXP-184 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis wild type, cop1-4, hy5-1 mutant seedlings exposed to polychromatic radiation
Seven-day-old white-light-grown wild-type, cop1-4 or hy5-1 mutant Arabidopsis seedlings were exposed for fifteen minutes to polychromatic radiation with decreasing short-wave cut-off in the UV range (WG305 = +UV-B, WG327 = -UV-B) and samples were taken 1 h after the onset of irradiation.
ORGANISM(S): Arabidopsis thaliana 
2006-08-16 | E-MEXP-557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiating mouse embryonic fibroblasts generated from wild type and PKBa-/- mice to study the role of PKBa in adipose differentiation.
Mouse embryonic fibroblasts (MEFs) were generated from 13.5-day-old embryos obtained from heterozygous PKBa mice intercrosses (Yang et al., 2003). Briefly, after dissection of head and visceral organs for genotyping, embryos were minced and trypsinized for 30 min at 37°C. Embryonic fibroblasts were ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2746 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP_chip]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30204 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis response to UV-B
Seven-day-old white-light-grown Arabidopsis seedlings were exposed for 15 minutes to polychromatic radiation with decreasing short-wave cut-off in the UV range, transferred back to the standard growth chamber and samples were taken 1 and 6 hours after the start of irradiation.
ORGANISM(S): Arabidopsis thaliana 
2006-03-01 | E-MEXP-550 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [RNA_seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-30280 | biostudies-arrayexpress
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