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TranscriptomicsCoupled pre-mRNA and mRNA dynamics unveil the operation strategies underlying transcriptional responses
Transcriptional responses to stimuli are regulated by tuning rates of transcript production and degradation. Here we show that stimulation-induced changes in transcript production and degradation rates can be inferred from simultaneously measured precursor mRNA (pre-mRNA) and mature mRNA profiles. O...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24391 | biostudies-arrayexpress
TranscriptomicsTechnical and biological variance structure in mRNA-Seq data
mRNA expression data from next generation sequencing platforms is obtained in the form of counts per gene or exon. Counts are generally assumed to follow a Poisson distribution in which the variance is equal to the mean. However, it is common in observed count data with biological variation for over...
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-29022 | biostudies-arrayexpress
TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
ProteomicsProteome changes as consequence of altered c-di-GMP metabolism in BCG
Pellicles, a type of biofilm, have gathered a renewed interest in the field of tuberculosis as a structure that mimics some characteristics occurring during M. tuberculosis infection, such as antibiotic recalcitrance and chronicity of infection. In other bacteria, it has been well documented that th...
ORGANISM(S): Mycobacterium bovis BCG str. Pasteur 1173P2 
2018-03-21 | PXD005894 | Pride
C-di-gmp Mycobacteria Pellicle Proteome 
TranscriptomicsExpression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors DASL Cancer Panel
HER2-positive and HER2-negative samples are compared within this DASL Cancer Panel Platform Two-class comparison
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-25231 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Formalin-Fixed Parafin-Embedded Primary Breast Tumors Whole Genome DASL
HER2-positive and HER2-negative samples are compared within this Whole Genome Platform Two-class comparison
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-25233 | biostudies-arrayexpress
UnknownKRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.
Not available
S-EPMC11232480 | biostudies-literature
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