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ProteomicsMapping of phosphorylation target sites of obscurin-kin 1 within the cytoplasmic domain of N-cadherin by LC-MS/MS
To test our hypothesis that obscurin-kin1 modulates, at least in part, the mechanochemical coupling of cardiomyocytes via phosphorylation of N-cadherin, which has been shown to play a pivotal role in these processes, we set forth to identify the potential phosphorylation target sites of obscurin-kin...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD031003 | Pride
Cytoplasmic domain of n-cadherin Obscurin kinase 1 Ser phosphorylation Lc-ms/ms 
UnknownExploring Obscurin and SPEG Kinase Biology.
Not available
S-EPMC7957886 | biostudies-literature
TranscriptomicsControl shRNA- vs. obscurin shRNA-expressing MCF10A cells
Obscurins (~70-870kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impli...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35494 | biostudies-arrayexpress
UnknownEssential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation.
Not available
S-EPMC10967385 | biostudies-literature
UnknownBinding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle.
Not available
S-EPMC4582401 | biostudies-literature
UnknownDouble the trouble: giant proteins with dual kinase activity in the heart.
Not available
S-EPMC7429600 | biostudies-literature
UnknownA LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
Not available
S-EPMC4321865 | biostudies-literature
UnknownLoss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.
Not available
S-EPMC5589558 | biostudies-literature
ProteomicsExercise-responsive phosphoproteins in the heart
Endurance exercise improves cardiac performance and affords protection against cardiovascular diseases but the signalling events that mediate these benefits are largely unexplored. Phosphorylation is an widely studied post-translational modification involved in intracellular signalling, and to disco...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-08-24 | PXD006646 | Pride
Phosphoproteomics Exercise-response 
TranscriptomicsRibosome profiling in muscle reveals the translation landscape of the giant protein titin
Purpose: Ribosome profiling and RNA-Seq were used to map the location and abundance of translating ribosomes on mouse heart and skeletal muscle transcripts. Methods: Tissue was rapidly harvested and snap-frozen to minimize bias to the pool of translating ribosomes. RNA was prepared from a single ho...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-41246 | biostudies-arrayexpress
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