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MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
MetabolomicsUntargeted metabolomics of offspring rats in MIA model

Maternal immune activation is a significant environmental factor for neurodevelopmental diseases. Although gut bacteria and their metabolites are linked to behavioral deficits in NDDs, the roles of gut fungi and secondary fungal metabolites remain unclear. Here, we induced MIA via a single intrap...

2026-01-20 | MTBLS12687 | MetaboLights
MetabolomicsGut Microbiota Mediates Maternal PM2.5 Exposure-induced Neurodevelopmental Disorder in offspring via Disturbing the Glutamate Metabolism: Evidence from Multiomics Analysis

While accumulating evidence links maternal PM2.5 exposure to offspring neurodevelopmental impairments, yet the underlying biological pathways require further elucidation. To address this, female ICR mice are exposed to filtered air (FA) or concentrated ambient particulate matter (CAP) for three ...

2026-01-05 | MTBLS13599 | MetaboLights
MetabolomicsMulti-omics analysis reveals maternal gut microbiota-derived short-chain fatty acids and progesterone are associated with offspring birth weight in sows

Piglet birth weight is a key determinant of preweaning survival and subsequent growth performance, yet the role of maternal gut microbiota in relation to offspring birth weight in sows remains incompletely characterized. This study aimed to investigate the association between maternal gut microbi...

2026-02-22 | MTBLS13791 | MetaboLights
MetabolomicsSupplementing RP-Arg during the gestation and lactation periods of grazing sheep reprograms liver metabolism in offspring lambs by increasing IGF-1 in milk

The nutritional status of ewes during gestation and lactation is a key determinant of lamb growth performance. Supplementing rumen-protected arginine (RP-Arg) during these stages induces maternal metabolic adaptation, thereby maintaining fetal developmental homeostasis. However, the sustained eff...

2025-10-30 | MTBLS13239 | MetaboLights
TranscriptomicsGene expression profile in offspring born before vs. after maternal bariatric surgery
Evaluate differences in gene expression levels between offspring born after maternal bariatric surgery and their siblings born before surgery Offspring born after maternal bariatric surgery (AMS, N=23) vs. offspring born before maternal surgery (BMS, N=23)
ORGANISM(S): Homo sapiens 
2013-05-16 | E-GEOD-44407 | biostudies-arrayexpress
MetabolomicsMaternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle
Not available
ORGANISM(S): Papio hamadryas 
ST002254 | MetabolomicsWorkbench
TranscriptomicsMaternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring
Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-st...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-46359 | biostudies-arrayexpress
TranscriptomicsMaternal overnutrition causes insulin resistance and alters skeletal muscle oxidative phosphorylation in adult rat offspring
Maternal obesity can program metabolic syndrome in offspring but the mechanisms are not well characterized. Moreover, the consequences of maternal overnutrition in the absence of frank obesity remain poorly understood. This study aimed to determine the effects of maternal consumption of a high fat-s...
ORGANISM(S): Rattus norvegicus 
2013-08-13 | E-GEOD-49797 | biostudies-arrayexpress
TranscriptomicsThe direction of cross affects obesity after puberty in male but not female offspring
We investigated parent-of-origin and allele-specific expression effects on obesity and hepatic gene expression in reciprocal crosses between the Berlin Fat Mouse Inbred line (BFMI) and C57Bl/6NCrl (B6N). We sequenced mRNA extracted from liver tissue of 10 M. Musculus individuals. 4 liver samples wer...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-74889 | biostudies-arrayexpress
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