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TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsSF-1 and RNF31 knockdown and forskolin treatment
The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3259 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of S. pombe co-overexpressing DNA synthesis initiation factors cdc18 (cdc6) and cdt1 to investigate gene copy number increases
During S-phase of the eukaryotic cell cycle, controls exist to ensure that replication origins fire only once and become inactivated after traverse of a replication fork. Failure of these controls results in local amplification of the genome which can lead to gene copy increases important for both ...
ORGANISM(S): Schizosaccharomyces pombe 
2010-08-13 | E-MTAB-139 | biostudies-arrayexpress
UnknownResistance of South American opossums to vWF-binding venom C-type lectins.
Not available
S-EPMC8522506 | biostudies-literature
TranscriptomicsRegression of Cardiac Hypertrophy and Attenuation of Progression to Heart Failure by Paricalcitol Therapy in Rats
Background: Vitamin D deficiency is associated with cardiac hypertrophy and heart failure, and vitamin D therapy prevents the progression of cardiac hypertrophy in animal models. Here, we examine whether vitamin D therapy regresses pre-existing cardiac hypertrophy, and prevents the progression to he...
ORGANISM(S): Rattus norvegicus 
2010-09-14 | E-GEOD-24110 | biostudies-arrayexpress
UnknownMolecular epidemiology of coagulase-negative Staphylococcus species isolated at different lactation stages from dairy cattle in the United States.
Not available
S-EPMC6507897 | biostudies-literature
TranscriptomicsTranscription profilfing of human cerebrovascular smooth muscle to identify Ca2+-dependent transcription patterns
Altered Ca2+ handling has both immediate physiological effects and long-term genomic effects on vascular smooth muscle function. Previously we have shown that elevation of cytoplasmic Ca2+ through voltage-dependent Ca2+ channels (VDCCs) or store-operated Ca2+ channels (SOCCs) results in phosphoryla...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-2883 | biostudies-arrayexpress
TranscriptomicsLyngbyoic Acid, a "Tagged" Fatty Acid from a Marine Cyanobacterium, Disrupts Quorum Sensing in Pseudomonas aeruginosa
Quorum sensing (QS) is a mechanism of bacterial gene regulation in response to increases in population density. Production of small molecule QS signals, their accumulation within a diffusion-limited environment and their binding to the LuxR-type receptor trigger QS-controlled gene regulatory casca...
ORGANISM(S): Pseudomonas aeruginosa 
2011-01-24 | E-GEOD-22999 | biostudies-arrayexpress
UnknownCharacterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values.
Not available
S-EPMC12175843 | biostudies-literature
TranscriptomicsGene expression in the right ventricle of Rattus norvegicus during development of right ventricular heart failure and treatment
Right ventricular heart failure (RVF) associated with pulmonary hypertension (PH) is characterized by a distinct gene expression pattern when compared with functional compensatory hypertrophy. Carvedilol treatment after RVF has been established reduces right ventricle (RV) hypertrophy and improves...
ORGANISM(S): Rattus norvegicus 
2013-05-06 | E-GEOD-42579 | biostudies-arrayexpress
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