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ProteomicsRegulation of the DLC3 tumor suppressor by a novel phosphoswitch
Deleted in Liver Cancer 3 (DLC3) is a Rho GTPase-activating protein (RhoGAP) that plays a crucial role in maintaining adherens junction integrity and coordinating polarized vesicle transport by modulating Rho activity at the plasma membrane and endomembranes. By employing bioinformatical sequence an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD045808 | Pride
Cytokinesis Gtpase activating protein Rho signaling Polybasic region Membrane binding 
ProteomicsGFP-DLC1 interactome in MCF7 breast cancer cells
The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. The aim of this project was to identify novel interacti...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027186 | Pride
Breast cancer Mcf7 Dlc1 Rhogap 
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