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MetabolomicsCholic Acid as a Potential Mediator in PD Olfactory Dysfunction: Insights from Nasal Microbiome-Metabolite Interactions Research

Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms, including olfactory dysfunction, which often precedes motor symptoms by several years. However, the underlying mechanisms linking olfactory dysfunction in PD to bio...

2025-07-07 | MTBLS12692 | MetaboLights
TranscriptomicsThe human nose harbours a niche of olfactory ecto-mesenchymal stem cells displaying neurogenic and osteogenic properties
We previously identified multipotent stem cells within the lamina propria of the human olfactory mucosa, located in the nasal cavity. We also demonstrated that this cell type differentiates into neural cells and improves locomotor behavior after transplantation in a rat model of Parkinson’s diseas...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24598 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse olfactory epithelium frpm Harlequin mutants compared to littermate controls
Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons Experiment Overall Design: Olfactory epithelium from Harlequin mutant mice and littermate control mice was microdissected for RN...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6485 | biostudies-arrayexpress
MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
TranscriptomicsTranscription profiling of mouse olfactory epithelium from heterozygous and homozygouse OMP-GFP animals
OMP is expressed only in mature olfactory sensory neurons, arguing that its function is specially suited to the needs of OSNs. However none of the properties of OMP suggest any direct role in regulating gene expression in OSNs. Our data confirms that gene expression in the olfactory epithelium of m...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4927 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse olfactory sensory neurons
The overall aim of the experiment is to understand the phenotype of mature mouse olfactory sensory neurons by analyzing the transcripts expressed and enriched in them as compared to the rest of the cell types in the olfactory epithelium (consisting of immature neurons, supporting cells, progenitor c...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4915 | biostudies-arrayexpress
ProteomicsOlfactory proteomics in amyotrophic lateral sclerosis
Despite smell impairment has been considered a potential non-motor finding in ALS, the pathobiochemistry at olfactory level remains unknown. Here, we applied an olfactory quantitative proteotyping approach to analyze the magnitude of the olfactory bulb (OB) proteostatic imbalance in ALS subjects (n=...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021630 | Pride
Olfactory bulb Proteomics Olfactory marker protein Amyotrophic lateral slcerosis 
TranscriptomicsTranscriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheating cells and Schwann cell-like glia
The objective of this study was to compare the transcriptomes of uninfected and canine distemper virus-infected Schwann cells, olfactory ensheating cells, central nervous system Schwann cell-like glia, and fibroblasts cultured under identical conditions in vitro.
ORGANISM(S): Canis familiaris 
2014-06-02 | E-MTAB-2061 | biostudies-arrayexpress
TranscriptomicsCopper-induced deregulation of microRNA expression in the zebrafish olfactory system
Although environmental trace metals, such as copper (Cu), can disrupt normal olfactory function in fish, the underlying molecular mechanisms of metal-induced olfactory injury have not been elucidated. Current research has suggested the involvement of epigenetic modifications. To address this hypothe...
ORGANISM(S): Danio rerio 
2014-04-30 | E-GEOD-46891 | biostudies-arrayexpress
TranscriptomicsInflammation and degeneration of the olfactory epithelium in an immuno-deficient zebrafish
Vertebrates are protected from pathogens by an adaptive and an innate immune system. In mammals, loss of the adaptive immune system severely compromises viability. Zebrafish, in contrast, can survive for relatively long without adaptive immunity, as demonstrated by the immuno-deficient Rag1 mutant. ...
ORGANISM(S): Danio rerio 
2010-06-20 | E-GEOD-9260 | biostudies-arrayexpress
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