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ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-25 | PXD010383 | Pride
Tandem mass tags Lc-ms Proteome Oligodendrocyte cell progenitor cell 
TranscriptomicsCD133/CD140a-Based Isolation of Distinct Human Multipotent Neural Progenitor Cells and Oligodendrocyte Progenitor Cells
The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated t...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-40676 | biostudies-arrayexpress
ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-22 | PXD013708 | Pride
Opc ageing Proteomics Primary cells 
TranscriptomicsRapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Stem cell biology has garnered much attention due to its potential to impact human health through disease modeling and cell replacement therapy. This is especially pertinent to myelin-related disorders such as multiple sclerosis and leukodystrophies where restoration of normal oligodendrocyte funct...
ORGANISM(S): Mus musculus 
2011-10-02 | E-GEOD-31562 | biostudies-arrayexpress
TranscriptomicsThe difference of gene expression in mouse OPCs in normothermic and hypothermic culture
We have found that the cell yield of oligodendrocyte precursor cells (OPCs) are higher in 31.5 degC than in 37 degC not by suppression of apoptosis but by enhancement of proliferation. Here, we performed transcriptome analysis using Affymetrix GeneChip on the primary cultured oligodendrocyte precurs...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-20645 | biostudies-arrayexpress
TranscriptomicsDirect Conversion of Fibroblasts into Oligodendrocyte Progenitor Cells
Many studies have already shown the reprogramming of somatic cells into other cell types such as neural stem cells, blood progenitor cells, and hepatocytes by inducing combinations of transcription factors. One of the recent development in cellular reprogramming is the direct reprogramming, that can...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-52035 | biostudies-arrayexpress
TranscriptomicsCandidate pathways for promoting differentiation and quiescence of oligodendrocyte progenitor-like cells in glioblastoma
The mature CNS contains PDGFRA+ ‘oligodendrocyte progenitor cells’ (OPC) which may remain quiescent, proliferate, or differentiate into oligodendrocytes. In human gliomas, rapidly proliferating Olig2+ cells resembling OPCs are frequently observed. We sought to identify, in vivo, candidate pathways u...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-30626 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
UnknownNon-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function.
Not available
S-EPMC7867598 | biostudies-literature
UnknownPericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.
Not available
S-EPMC5574064 | biostudies-literature
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