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TranscriptomicsTranscription profiling of human adult male germ cell tumours
Expression profiling of a panel of 101 adult male germ cell tumors and 5 normal testis specimens was performed on Affymetrix U133A and U133B microarrays. This data has been used to:; 1) generate a gene classifier that predicts histology (see PMID 15870693). 2) identify candidate target genes on 12p,...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3218 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary breast tumors and MDA-MB-231 subpopulations
Subpopulations of MDA-MB-231 that exhibit different metastatic tropisms when injected into immuno-deficient mice. Also, a cohort of primary breast cancers surgically resected at the Memorial Sloan-Kettering Cancer Center (MSKCC).
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2603 | biostudies-arrayexpress
GenomicsRecurrent epimutations activate gene body promoters in primary glioblastoma
Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly understood. We assayed the GBM methylome with MeDIP-seq and MRE-seq, adjusting for copy number differences, in a small set of non-glioma CpG isl...
EGAS00001000685 | EGA
UnknownDifferentially expressed genes in window trials are influenced by the wound healing process: lessons learned from a pilot study with Anastrozole
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-26544 | biostudies-other
TranscriptomicsDifferentially expressed genes in window trials are influenced by the wound healing process: lessons learned from a pilot study with Anastrozole
Introduction: Peri-operative window trials, using molecular biomarkers as surrogate endpoints for treatment response, offer investigators a uniqueopportunity to obtain intact tumor samples at 2 different time-points and thus evaluate potential biomarkers over a short period of time. Here we report r...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26544 | biostudies-arrayexpress
GenomicsQuantification of chromosomal copy number aberrations by shallow whole-genome sequencing
Detection of DNA copy number aberrations by shallow whole-genome sequencing (WGS) faces many challenges including lack of completion and errors in the human reference genome, repetitive sequences, polymorphisms, variable sample quality, and biases in the sequencing procedures. Formalin-fixed paraffi...
EGAS00001000642 | EGA
TranscriptomicsImmunomagnetic enrichment and flow cytometric isolation of breast cancer circulating tumor cells (CTCs) for genomic characterization
We developed a novel approach to isolate tumor cells with high purity from blood via immunomagnetic enrichment followed by fluorescence activated cell sorting (IE/FACS) and examined copy number alterations in these cells. Magnetic beads coated with EpCAM mAb were added to blood to enrich for tumor c...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-27511 | biostudies-arrayexpress
GenomicsGenome-wide DNA Methylation is Predictive of Outcome in Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in this disease vary dramatically from spontaneous resolution with little or no treatment to rapid relapse after hematopoietic stem cell transplantation. Given the h...
EGAS00001002700 | EGA
GenomicsE.Stieglitz_20171027_dataset_aligned - samples
Description not provided
EGAD00001003794 | EGA
GenomicsJ_Costello_20140127_dataset - samples
Dataset contains MeDIP-Seq, MRE-Seq and H3K4me3 ChIP-Seq data on 5 GBM patients.
EGAD00001000777 | EGA
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