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TranscriptomicsExpression data from intestine of HDAC1 and HDAC2 conditionally mutated mice
Acetylation and deacetylation of histones and other proteins depend on the opposing activities of histone acetyltransferases and histone deacetylases (HDACs), leading to either positive or negative gene expression changes. The use of HDAC inhibitors (HDACi) has uncovered a role for HDACs in the cont...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-47745 | biostudies-arrayexpress
TranscriptomicsMyocardin-related Transcription Factors Are Required for Skeletal Muscle Development
Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics. Stimuli that promote actin polymerization allow for shuttling of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and other c...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-84063 | biostudies-arrayexpress
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
UnknownInterferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.
Not available
S-EPMC7456374 | biostudies-literature
TranscriptomicsFunctional Roles of Hdac1/2 in lung development
Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we per...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human-melanoma derived cell lines response to chemotherapy
To identify patterns of gene expression that correlate with response to treatment with either melphalan or temozolomide we measured both gene expression using microarray genechips and response to drug using a standard in vitro cell proliferation assay. Senstivity to melphalan was measured 48hrs aft...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-10916 | biostudies-arrayexpress
UnknownStaphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.
Not available
S-EPMC5144732 | biostudies-literature
TranscriptomicsExpression data from HDAC1 and HDAC2 knocked-out mouse oocyte
Dramatic changes in chromatin structure and histone modification occur during oocyte growth, as well as a global cessation of transcription. The role of histone modifications in these processes is poorly understood. We report the effect of conditionally deleting Hdac1 and Hdac2 on oocyte development...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-34786 | biostudies-arrayexpress
UnknownDNA deformability defines sequence-dependent capture of <i>E. coli</i> gyrase.
Not available
S-EPMC12393610 | biostudies-literature
TranscriptomicsRNA-Seq and BS-Seq of Sorghum bicolor tissues
This study utilized next generation sequencing technology (RNA-Seq and BS-Seq) to examine the transcriptome and methylome of various tissues within sorghum plants with the ultimate goal of improving the Sorghum bicolor annotation We examined the mRNA of various Sorghum bicolor (BTx623) tissues (flow...
ORGANISM(S): Sorghum bicolor 
2014-08-29 | E-GEOD-50464 | biostudies-arrayexpress
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