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ProteomicsCharacterizing T-cell immunopeptidomes
Imunopeptidomes promise novel surface markers as ideal targets for immunotherapies, but their characterization by mass spectrometry (MS) remains challenging. Until recently, cell numbers exceeding 1.0xE9 were needed for reasonably deep immunopeptidome surveys of at least 1,000 HLA ligands. Such limi...
ORGANISM(S): Homo sapiens (Human) 
2018-03-08 | PXD007860 | Pride
Human Antigen presentation T cell Mhc Orbitrap 
TranscriptomicsMicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS) miRNA
MicroRNAs are small noncoding RNA molecules that are involved in the control of gene expression. To investigate the role of microRNA in multiple sclerosis (MS), we performed global microarray analyses of mRNA and microRNA in peripheral blood T-cells from relapsing-remitting MS patients and controls....
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-43590 | biostudies-arrayexpress
TranscriptomicsMicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS) mRNA
MicroRNAs are small noncoding RNA molecules that are involved in the control of gene expression. To investigate the role of microRNA in multiple sclerosis (MS), we performed global microarray analyses of mRNA and microRNA in peripheral blood T-cells from relapsing-remitting MS patients and controls....
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-43591 | biostudies-arrayexpress
TranscriptomicsEpigenome-wide DNA methylation profiling in cord blood CD4+ T cells from children treated prenatally with Lactobacillus reuteri and/or omega-3 fatty acids
In this study, we have examined the effect of combined prenatal Lactobacillus reuteri and omega-3 fatty acid supplementation on DNA methylation patterns in neonatal immune cells from children with a high propensity of developing allergies. We addressed this matter by assessing epigenome-wide DNA met...
ORGANISM(S): Homo sapiens 
2021-03-31 | E-MTAB-10341 | biostudies-arrayexpress
TranscriptomicsMicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-43179 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44964 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
TranscriptomicsMicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [miRNA]
MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that diffe...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-43178 | biostudies-arrayexpress
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in hu...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD004746 | Pride
Human Mhc Mantle cell lymphoma Antigen presentation Ltq orbitrap elite 
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in huma...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005704 | Pride
Human Antigen presentation Ltq orbitrap elite Mhc class i 
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