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ProteomicsLipid droplet-targeted APEX proteome
Lipid droplet (LD) function is regulated by a complement of integral and peripheral proteins that associate with the LD phospholipid monolayer. Defining the composition of the LD proteome has remained a challenge due to the presence of contaminating proteins in LD-enriched buoyant fractions. To over...
ORGANISM(S): Homo sapiens (Human) 
2017-12-22 | PXD007695 | Pride
Lipid droplet Apex Erad 
ProteomicsHrd1 interaction proteomics - Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the degradation of misfolded and unoligomerized proteins in the early secretory pathway. ERAD substrates are detected and delivered to membrane-embedded dislocation complexes. Following transfer into the cytosol, substrates are rapidl...
ORGANISM(S): Homo sapiens (Human) 
2017-01-03 | PXD005633 | Pride
Erad Hrd1 Triacsin c 
ProteomicsEndoplasmic reticulum di-glycine modified proteome under p97/VCP inhibition
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S prote...
ORGANISM(S): Homo sapiens (Human) 
2018-03-12 | PXD008842 | Pride
Erad Digly Ubiquitin 
ProteomicsLow Density Lipoprotein Receptor Targeting Chimeras for Membrane Protein Degradation and Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells, among which antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depend on efficient lysosomal trafficking for activity. However, many tumor antigens exhibit poor interna...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD064642 | Pride
Antibody based degradation 
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