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TranscriptomicsFKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance.
Glucocorticoid excess is linked to central obesity, adipose tissue insulin resistance and type 2 diabetes mellitus. The aim of our study was to investigate the effects of dexamethasone on gene expression in human subcutaneous and omental adipose tissue, in order to identify potential novel mechanism...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-42902 | biostudies-arrayexpress
ProteomicsIdentification of the novel function of adipocyte plasma membrane associated protein (APMAP) in gestational diabetes mellitus by proteomic analysis of omental adipose tissues
Gestational diabetes mellitus (GDM) is considered as the early stage of type 2 diabetes mellitus. In this study, we compared the demographic and clinical data between six GDM and six NGT (healthy controls) and found the HOMA-IR was increased in GDM. Previously, many researches had proved that omenta...
ORGANISM(S): Homo sapiens (Human) 
2016-02-02 | PXD003095 | Pride
Omental adipose tissues Gestational diabetes mellitus Label-free proteomics 
ProteomicsIdentification of the novel function of adipocyte plasma membrane associated protein (APMAP) in gestational diabetes mellitus by proteomic analysis of omental adipose tissues
Gestational diabetes mellitus (GDM) is considered as the early stage of type 2 diabetes mellitus. In this study, we compared the demographic and clinical data between six GDM and six NGT (healthy controls) and found the HOMA-IR was increased in GDM. Previously, many researches had proved that omenta...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080798 | MassIVE
TranscriptomicsIndividualized analysis of subcutaneous and omental abdominal adipose tissue from non-obese and obese subjects
Individualized analysis through expression profiling of 20,000 probes in 28 tissue samples evaluated in subcutaneous and omental adipose tissue obtained during surgical intervention in non-obese and obese patients. Patients consisted of men and women of varying body size (lean to severely obese). Sa...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15524 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adipose tissue using an expanded patient cohort
Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expre...
ORGANISM(S): Homo sapiens 
2010-04-07 | E-GEOD-20950 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss
Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this wo...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of omental adipose tissues in human obesity by RNA-Seq
Purpose: To profile the transcriptomes of omental adipose tissues from obese and lean humans. Methods: Omental adipose tissues from obese and lean patients were subjected to RNA-Seq. Results: Differential expression analysis identified 206 dysregulated genes (p-value < 0.05 by moderated t-test and f...
ORGANISM(S): Homo sapiens 
2015-02-11 | E-GEOD-55008 | biostudies-arrayexpress
TranscriptomicsGlucocoritcoid regulated genes in omental and subcutaneous human adipose tissues
To provide a comprehensive understanding of how GC affect adipose tissue and adipocyte function, we analyzed patterns of gene expression after culture of abdominal subcutaneous (sc) and omental (Om)) Adipose tissue of severely obese subjects (3F, 1M) in the presence of insulin or insulin (7 nM) plus...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-26123 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans
Adipose tissues play an important role in the pathophysiology of obesity-related disease including type 2 diabetes. To describe gene expression patterns and functional pathways in obesity-related type 2 diabetes, we performed global transcript profiling of omental adipose tissue in morbidly obese in...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-71416 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Subcutaneous, Omental, and Retroperitoneal Adipose Tissues in a Cohort of Healthy Human Kidney Donors
This experiment aims to deepen our understanding of adipose tissue biology and its implications for metabolic and kidney health. The experimental workflow includes biopsy collection during surgery and total RNA extraction from each sample. Then cDNA libraries were prepared and used for high-throughp...
ORGANISM(S): Homo sapiens 
2024-11-01 | E-MTAB-13869 | biostudies-arrayexpress
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