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MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
TranscriptomicsIntegrative Multi-Omics Reveal Metabolic Reprogramming by Ketogenic Diet in Melanoma Xenografts
The ketogenic diet (KD) has demonstrated anti-proliferative effects across multiple tumor types, yet the underlying metabolic and transcriptomic mechanisms remain incompletely understood. This study employed integrated multi-omics analysis combining targeted metabolomics and RNA-sequencing to elucid...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-16979 | biostudies-arrayexpress
GenomicsSingle Cell triple omics sequencing reveals genetic and epigenetic heterogeneity in hepatocellular carcinoma
Single cell genome, DNA methylome, and transcriptome sequencing has been achieved separately. However, to analyze the regulation of RNA expression by genetic and epigenetic factors within an individual cell, it is necessary to analyze these omics simultaneously from the same single cell. Here we dev...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-65364 | biostudies-arrayexpress
TranscriptomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation – from exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo sapiens 
2024-02-22 | E-MTAB-12751 | biostudies-arrayexpress
ProteomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation. From exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091157 | MassIVE
TranscriptomicsIntegrated analysis of omics profiles
This SuperSeries is composed of the following subset Series: GSE32691: Autoantibody profile timecourse of UNK GSE32874: Personal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-33029 | biostudies-arrayexpress
TranscriptomicsPersonal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyome...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-32874 | biostudies-arrayexpress
TranscriptomicsAVATARS - Tissue-specific multi-omics analyses in developing Brassica napus seeds [mRNA-Seq]
In this project, we developed a data resource based on the German winter oilseed rape cultivar Express 617. Plants were grown under controlled environmental conditions in the container-based system of the IPK PhenoSphere in 2020-2021. The dataset comprises gene expression data generated by RNA seque...
ORGANISM(S): Brassica napus 
2025-03-19 | E-MTAB-14603 | biostudies-arrayexpress
ProteomicsHuman Ebola Virus Disease Pathogenesis Multi-Platform Omics Analysis
Multi-platform omics analyses of peripheral blood mononuclear cells and plasma derived from human patients infected with Ebola virus.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080129 | MassIVE
TranscriptomicsSNP array Multi-omics molecular profiling of primary prostate adenocarcinoma
Multi-omics molecular profiling was performed on post-radical prostatectomy material from a cohort of 132 patients with localized prostate adenocarcinoma. Unsupervised classification techniques were used to build a comprehensive classification of prostate tumours based on three molecular levels: DNA...
ORGANISM(S): Homo sapiens 
2018-07-09 | E-MTAB-6127 | biostudies-arrayexpress
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