Oncogene addiction

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Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center (1)
Medical Biotechnology Center, VIB, Ghent, Belgium. Department of Biochemistry, Ghent University, Ghent, Belgium; (1)
Research Group Leader: Lung Carcinogenesis Comprehensive Pneumology Center Helmholtz Center Munich Member of the German Center for Lung Research Max-Lebsche-Platz 31, 81377 Munich [T] +498931874846 [F] +498931874661 [E] stathopoulos@helmholtz-muenchen.de [U] http://www.helmholtz-muenchen.de/ilbd (1)
St. Jude Children's Research Hospital (1)
University of Bern, Inselspital (1)

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An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies

Oncogene addiction provides important therapeutic opportunities for precision oncology treatment strategies. To date the cellular circuitries associated with driving oncoproteins, which eventually establish the phenotypic manifestation of oncogene addiction remain largely unexplored. We employed a t...

ORGANISM(S): Homo sapiens (Human)

2023-03-11 | PXD037406 | Pride

Mechanism of Oncogene Addiction

PRJNA302297 | ENA

The role of microRNA miR-17-92 in MYC oncogene addiction

miR-17-92 mediates the MYC oncogene addiction in a conditional mouse lymphoma model. To identify targets of miR-17-92 in this model, miR-17-92 was expressed in the conditional lymphoma cell lines using MSCV-puro. Both control and miR-17-92-expressing conditional lymphoma cell lines were treated wit...

ORGANISM(S): Mus musculus

2014-05-29 | E-GEOD-57507 | biostudies-arrayexpress

Oncogene addiction to GNAS in GNASR201 mutant tumors

PRJNA859019 | ENA

Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction

The suppression of oncogenic levels of MYC is sufficient to induce sustained tumor regression associated with proliferative arrest, differentiation, cellular senescence and/or apoptosis, a phenomenon known as oncogene addiction. However, after prolonged inactivation of MYC in a conditional transgeni...

ORGANISM(S): Mus musculus

2011-09-23 | E-GEOD-32341 | biostudies-arrayexpress

Non-oncogene addiction to SIRT3 plays a critical role in lymphomagenesis

PRJNA541280 | ENA

Oncogene-like addiction to aneuploidy in human cancers

PRJNA921841 | ENA

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.

Not available

S-EPMC5464975 | biostudies-literature

Stabilized biological production by product addiction

Populations of engineered metabolite-producing microorganisms are prone to evolutionary production declines during industrial-scale cultivations. In this study, we develop a synthetic product addiction system in E coli that addicts mevalonic acid production cells to mevalonic acid. Through experimen...

ORGANISM(S): Escherichia coli K-12

2018-02-09 | E-MTAB-6182 | biostudies-arrayexpress

Transcriptional Targeting Of Oncogene Addiction In Medullary Thyroid Cancer

PRJNA464052 | ENA

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