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MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-15 | MTBLS13145 | MetaboLights
MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-23 | MTBLS13148 | MetaboLights
TranscriptomicsBulk RNA-Sequencing of brain hemispheres of mice with colitis induced by intestinal epithelial-specific Opa1 deletion
Whole right brain hemispheres of mice with colitis caused by induced, intestinal epithelial-specific Opa1 knock-out to study the impact of gut inflammation on the brain
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-15483 | biostudies-arrayexpress
TranscriptomicsBulk RNA-sequencing of defined brain regions of mice with chronic DSS-induced colitis and colitis induced bz intestinal epithelial-specific Opa1 deletion
Selected brain regions of mice with chronic DSS colitis and controls, and mice with colitis caused by induced, intestinal epithelial-specific Opa1 knock-out to study the impact of gut inflammation on the brain
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-15488 | biostudies-arrayexpress
ProteomicsHeart proteome in Cox10 depending on Opa1 processing
Mitochondrial fusion and fission accompany adaptive responses to stress and altered metabolic demands. Inner membrane fusion and cristae morphogenesis depends on Optic Atrophy 1 (Opa1), which is expressed in different isoforms and is cleaved from a membrane-bound, long to a soluble, short form. Here...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD048804 | Pride
Heart Cox10 Opa1 
GenomicsOPA1 mice gut micobiome
OPA1 mice gut micobiome
PRJEB83275 | ENA
GenomicsRNA sequencing of Opa1-silenced HUVECs.
RNA sequencing of Opa1-silenced HUVECs.
PRJNA503252 | ENA
ProteomicsOptic Atrophy 1 (OPA1) overexpression promotes dyslipidemia and atherosclerosis coupled to altered aortic VSMC function in LDL-R deficient mice.
Aims: Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, sterol and bile acids (BAs) synthesis. Mitochondria are plastic organelles and continuously undergo biogenesis, fusion, fission and mitophagy. On these premises, we tested how the overexpression of OPA1, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD060456 | Pride
Atherosclerosis Opa1 Dyslipidemia Mithocondria 
GenomicsGenome-wide analysis of Ctr and OPA1 knock-down transcriptomes
Genome-wide analysis of Ctr and OPA1 knock-down transcriptomes
PRJNA557415 | ENA
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