Sort   by:  
 Page size 
ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-22 | PXD013708 | Pride
Opc ageing Proteomics Primary cells 
TranscriptomicsExpression profile of OPC senescence
To identify factors involved in OPC senescence, we compared gene expressions between OPC-CG4, OPC-FCS and OPC-Rev. We established OPC senescence model system, in which OPC become senescent in the presence of high concentration of FCS. This phenotypes were kept even when the medium was switched to th...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-28093 | biostudies-arrayexpress
ProteomicsDelaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2
Myelin aging is a driving force of CNS aging, and age-dependent declined efficiency of remyelination caused by impaired differentiation capacity of aged oligodendrocyte precursor cell (OPC) is a major cause of demyelinated diseases. Revealing how differentiation capacity of aged OPC is affected meta...
ORGANISM(S): Rattus Norvegicus 
2020-10-18 | PXD022046 |
ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-25 | PXD010383 | Pride
Tandem mass tags Lc-ms Proteome Oligodendrocyte cell progenitor cell 
UnknownRestoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing.
Not available
S-EPMC8907257 | biostudies-literature
UnknownNiche stiffness underlies the ageing of central nervous system progenitor cells.
Not available
S-EPMC7025879 | biostudies-literature
UnknownChanges in the Oligodendrocyte Progenitor Cell Proteome with Ageing.
Not available
S-EPMC8015006 | biostudies-literature
TranscriptomicsYoung CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing. Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds. We discovered that infusing y...
ORGANISM(S): Mus musculus Rattus norvegicus 
2022-05-11 | GSE198008 | GEO
UnknownClemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cells.
Not available
S-EPMC10876931 | biostudies-literature
UnknownRestoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion.
Not available
S-EPMC3911923 | biostudies-literature
Sort   by:  
 Page size